{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T07:33:00Z","timestamp":1771745580794,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the presence of myocardial injury in dogs hospitalized for snake envenomation and to examine its relationship with systemic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital and small animal referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Dogs naturally envenomed by the European viper (<jats:italic>Vipera berus<\/jats:italic>; <jats:italic>n<\/jats:italic> = 24), African puff adder (<jats:italic>Bitis arietans<\/jats:italic>; <jats:italic>n<\/jats:italic> = 5), or snouted cobra (<jats:italic>Naja annulifera<\/jats:italic>; <jats:italic>n<\/jats:italic> = 9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Blood was collected from dogs envenomed by <jats:italic>V. berus<\/jats:italic> at admission, 12\u201324 hours postadmission, and 5\u201310 days postadmission. Blood was collected from dogs envenomed by <jats:italic>B. arietans<\/jats:italic> or <jats:italic>N. annulifera<\/jats:italic> at admission, and 12, 24, and 36 hours postadmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Concentrations of cardiac troponin I (cTnI), a marker of myocardial injury, and C\u2010reactive protein (CRP), a marker of systemic inflammation, were measured in each blood sample. Evidence of myocardial injury was found in 58% of dogs envenomed by <jats:italic>V. berus<\/jats:italic> at one or more time points. A significant correlation between cTnI and CRP concentrations was found at all time points. Evidence of myocardial injury was found in 80% of dogs envenomed by <jats:italic>B. arietans<\/jats:italic> at one or more time points; however, no correlation was found between cTnI and CRP concentrations. Evidence of myocardial injury was found in 67% of dogs envenomed by <jats:italic>N. annulifera<\/jats:italic> at one or more time points. A significant correlation between cTnI and CRP concentrations was found at admission, but not at other time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Myocardial injury frequently occurred in dogs with snake envenomation. While the degree of systemic inflammation was significantly correlated with degree of myocardial injury in <jats:italic>V. berus<\/jats:italic> envenomation at all time points, this was not the case in dogs envenomed by <jats:italic>N. annulifera<\/jats:italic> or <jats:italic>B. arietans<\/jats:italic>. This could be due to differences in the toxic substances of the snake venoms or to differences in the cytokines induced by the venom toxins.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12127","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T21:46:45Z","timestamp":1386193605000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Myocardial injury in dogs with snake envenomation and its relation to systemic inflammation"],"prefix":"10.1111","volume":"24","author":[{"given":"Rebecca","family":"Langhorn","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical and Animal Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frida","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical and Animal Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"\u00c5blad","sequence":"additional","affiliation":[{"name":"The Blue Star Animal Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Goddard","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences University of Pretoria  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan P.","family":"Schoeman","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences University of Pretoria  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob L.","family":"Willesen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical and Animal Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Tarnow","sequence":"additional","affiliation":[{"name":"Chr. 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