{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:34:00Z","timestamp":1792103640640,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:00:00Z","timestamp":1410220800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To validate the i\u2010STAT, a portable hand\u2010held analyzer that allows point\u2010of\u2010care measurement of blood gases, acid\u2013base, lactate, and other blood variables in food animal practice for analysis of blood samples of newborn calves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>A total of 271 venous blood samples were analyzed for PvO<jats:sub>2<\/jats:sub>, PvCO<jats:sub>2<\/jats:sub>, pH, base excess (BE), HCO<jats:sub>3<\/jats:sub>, venous saturation of oxygen (SvO<jats:sub>2<\/jats:sub>), and total carbon dioxide (TCO<jats:sub>2<\/jats:sub>) using an i\u2010STAT and a Rapidlab 248 bench top analyzer that served as the reference method. <jats:sc>l<\/jats:sc>\u2010lactate was measured using the i\u2010STAT as well as photometrically. Results from the i\u2010STAT and the reference methods were compared. The analytes BE, HCO<jats:sub>3<\/jats:sub>, and TCO<jats:sub>2<\/jats:sub> showed a constant systematic error across the entire range with 2.3, 1.9, and 2.0 mmol\/L lower values, respectively, than the values measured by the reference method. Based on the combined inherent imprecision of the 2 analyzers and after correcting the influences of systematic errors, the PvO<jats:sub>2<\/jats:sub>, HCO<jats:sub>3<\/jats:sub>, and SvO<jats:sub>2<\/jats:sub> were within the acceptable limits in 76% to 91% of the cases. Ninety\u2010five percent of the measurements of PvCO<jats:sub>2<\/jats:sub> and BE were within acceptable limits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The overall performance of the i\u2010STAT was good except for BE, HCO<jats:sub>3<\/jats:sub>, and TCO<jats:sub>2<\/jats:sub>, thus limiting its usefulness in clinical studies. However this hand\u2010held device allows rapid, reliable, and accurate point\u2010of\u2010care blood analyses and thus can be useful in bovine practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12228","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T17:21:15Z","timestamp":1410283275000},"page":"519-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of the i\u2010STAT portable point\u2010of\u2010care analyzer for determination of blood gases and acid\u2013base status in newborn calves"],"prefix":"10.1111","volume":"24","author":[{"given":"Ulrich","family":"Bleul","sequence":"first","affiliation":[{"name":"Department of Farm Animals Clinic of Reproductive Medicine Vetsuisse\u2010Faculty University of Zurich  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of Farm Animals Clinic of Reproductive Medicine Vetsuisse\u2010Faculty University of Zurich  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731108001699"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2007.10.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.20.688"},{"key":"e_1_2_7_5_1","first-page":"205","article-title":"Role of acid\u2010base disturbances in perinatal mortality of calves","volume":"33","author":"Szenci O","year":"1985","journal-title":"Acta Vet Hung"},{"key":"e_1_2_7_6_1","first-page":"78","article-title":"Asphyxie des neugeborenen Kalbes","volume":"58","author":"M\u00fclling M","year":"1976","journal-title":"Prakt Tierarzt Collegium Veterinarium"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.135.5.111"},{"key":"e_1_2_7_8_1","first-page":"79","article-title":"Correlations between muscle tone and acid\u2010base balance in newborn calves: experimental substantiation of a simple new score system proposed for neonatal status diagnosis","volume":"30","author":"Szenci O","year":"1982","journal-title":"Acta Vet Hung"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinchem\/39.2.283","article-title":"Evaluation of a novel point\u2010of\u2010care system, the i\u2010STAT portable clinical analyzer","volume":"39","author":"Erickson KA","year":"1993","journal-title":"Clin Chem"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00258.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870701900407"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(02)00065-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.5.515"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(89)90287-2"},{"key":"e_1_2_7_15_1","unstructured":"N. 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