{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:17:48Z","timestamp":1770218268281,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004755","name":"University of Veterinary and Pharmaceutical Sciences Brno","doi-asserted-by":"crossref","award":["24\/2011\/IGA VFU Brno"],"award-info":[{"award-number":["24\/2011\/IGA VFU Brno"]}],"id":[{"id":"10.13039\/501100004755","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To (1) measure C\u2010reactive protein (CRP) and high mobility group box 1 (HMGB1) and (2) evaluate their prognostic value and relationship to severity of systemic inflammatory response syndrome, routine hematological and acid\u2010base parameters in dogs with gastric dilatation volvulus (GDV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study from September 2010 to June 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Veterinary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty\u2010one client\u2010owned dogs with GDV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Blood was collected before surgery (baseline), postsurgery, 6\u201310 hours postsurgery, and 18\u201322 hours postsurgery. CRP and HMGB1 were measured in all samples, and routine hematological, biochemical, and acid\u2010base analyses were performed. Only baseline and postsurgery samples were used from nonsurvivors (<jats:italic>n<\/jats:italic>= 10). CRP increased significantly from postsurgery sampling to 18\u201322 hours postsurgery, while HMGB1 did not change over time. There was a significant difference in HMGB1 between survivors and nonsurvivors over time. Both proteins correlated with systemic inflammatory response syndrome severity, total leukocyte, segmented neutrophils, and band counts. HMGB1 correlated also with acid\u2010base parameters (pH, bicarbonate, base excess).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HMGB1 and CRP behaved differently in regards to their kinetic patterns, with HMGB1 appearing to better reflect the severity of tissue injury in dogs with GDV than CRP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12324","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T21:34:49Z","timestamp":1434663289000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["C\u2010reactive protein and high mobility group box 1 in dogs with gastric dilatation and volvulus"],"prefix":"10.1111","volume":"25","author":[{"given":"Ivana","family":"Uhrikova","sequence":"first","affiliation":[{"name":"Department of Physiology Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leona","family":"Rauserova\u2010Lexmaulova","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Department of Surgery and Orthopedics Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Rehakova","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Laboratory University of Veterinary and Pharmaceutical Sciences Brno Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Scheer","sequence":"additional","affiliation":[{"name":"Department of Physiology Brno Czech Republic"},{"name":"Integrated Center of Cellular Therapy (ICCT) St. Annes\u00b4s University Hospital \u2010 International Clinical Research Center Brno Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Doubek","sequence":"additional","affiliation":[{"name":"Department of Physiology Brno Czech Republic"},{"name":"Small Animal Clinical Laboratory University of Veterinary and Pharmaceutical Sciences Brno Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00457.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.suppl_1.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0296.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00462.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063871002200308"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0731.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00940.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.487"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073415"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.6.1084"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1104648"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.09.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.07.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.10.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27894"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2010.00539.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0540"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1997.tb01699.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870802000214"},{"issue":"6","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2460\/ajvr.1987.48.06.919","article-title":"C\u2010reactive protein in dogs","volume":"48","author":"Caspi D","year":"1987","journal-title":"Am J Vet Res"},{"issue":"5","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2460\/ajvr.1994.55.05.613","article-title":"C\u2010reactive protein concentration in dogs with inflammatory leukograms","volume":"55","author":"Burton SA","year":"1994","journal-title":"Am J Vet Res"},{"issue":"5","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/ajcp\/66.5.840","article-title":"Quantitation of \u201cacute\u2010phase proteins\u201d postoperatively. 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