{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:54Z","timestamp":1791313014571,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of in vitro hemodilution with lactated Ringers solution (LRS), hetastarch (HES), and fresh frozen plasma (FFP) on whole blood coagulation in dogs as assessed by kaolin\u2010activated thromboelastography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>In vitro experimental study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six healthy client\u2010owned dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Whole blood was collected and diluted in vitro at a 33% and 67% dilution with either LRS, HES, or FFP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Kaolin\u2010activated thromboelastography was performed on each sample as well as a control. Thromboelastographic parameters <jats:italic>R<\/jats:italic> (min), alpha (deg), <jats:italic>K<\/jats:italic> (min), and MA (mm) were measured and compared to the sample control for each dilution using mixed model methodology. Prolongation in coagulation times were seen at both dilutions with LRS and HES. There was no significant difference in <jats:italic>R<\/jats:italic> times at the 33% dilution, but <jats:italic>R<\/jats:italic> time was significantly prolonged at the 67% dilution with HES (<jats:italic>P<\/jats:italic> = 0.004). MA was significantly decreased for LRS at both dilutions (<jats:italic>P<\/jats:italic> = 0.013, <jats:italic>P<\/jats:italic> &lt; 0.001) and more profoundly decreased for HES (<jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>P<\/jats:italic> = 0.006). No significant difference in any parameter was found for FFP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In vitro hemodilution of whole blood with both LRS and HES but not FFP resulted in significant effects on coagulation with HES having a more profound effect. In vivo evaluation of changes in coagulation with various resuscitation fluids is warranted and may be clinically relevant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12345","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T18:37:54Z","timestamp":1438108674000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of in vitro hemodilution with crystalloids, colloids, and plasma on canine whole blood coagulation as determined by kaolin\u2010activated thromboelastography"],"prefix":"10.1111","volume":"26","author":[{"given":"Bari R.","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine  North Grafton MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"deLaforcade","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine  North Grafton MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine  North Grafton MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine  North Grafton MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Meola","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine  North Grafton MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rozanski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine  North Grafton MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"423","volume-title":"Fluid, Electrolyte, and Acid\u2010base Disorders in Small Animal Practice","author":"DiBartola SP","year":"2011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00816.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei052"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.12.1908"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.6.605"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00464.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.5.712"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000197694.48429.94"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05385.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440914.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(98)00034-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.220-az0354.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200004000-00005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.04025.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2012.00431.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2011.00656.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00729.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00161.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0058.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.4.463"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200002000-00007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.6.789"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199908000-00006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200106000-00008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200003000-00008"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvec.12345","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.12345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T01:40:20Z","timestamp":1696038020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.12345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,28]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/vec.12345"],"URL":"https:\/\/doi.org\/10.1111\/vec.12345","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,28]]},"assertion":[{"value":"2013-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}