{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:41:04Z","timestamp":1773074464139,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Tennessee, College of Veterinary Medicine, Biomedical and Diagnostic Sciences Departmental Fund for Education Advancement and Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the utility of population\u2010based reference intervals (PRIs) for interpreting thromboelastography (TEG) variables in horses using biological variation data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort biologic variation study conducted over a 5\u2010week period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Veterinary teaching hospital and research facility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Ten clinically healthy horses randomly selected from a veterinary school research and teaching herd.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Horse health was determined using physical examination, CBC, and biochemical and coagulation profiles prior to the start of the study. Subsequently, once weekly blood sampling for TEG testing was performed for 5 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>The 4 TEG variables reaction time (<jats:italic>R<\/jats:italic>), clot formation time (<jats:italic>K<\/jats:italic>), angle, and maximum amplitude (MA) were measured, and coefficient of variation representing within\u2010 and between\u2010horse biological variation (CV<jats:sub>i<\/jats:sub> and CV<jats:sub>g<\/jats:sub>, respectively) and coefficient of variation representing analytical variation (CV<jats:sub>a<\/jats:sub>) were calculated using a nested ANOVA after removing outlier data. The CV<jats:sub>i<\/jats:sub>, CV<jats:sub>g<\/jats:sub>, and CV<jats:sub>a<\/jats:sub> for <jats:italic>R<\/jats:italic> were 26.8%, 5.2%, and 5.9%; for <jats:italic>K<\/jats:italic> were 31.0%, 0.0%, and 5.9%; for angle were 9.4%, 6.2%, and 21.7%; and for MA were 3.4%, 4.1%, and 4.4%, respectively. Index of individuality (IOI) was then calculated for each variable using the formula <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/vec12410-math-0001.png\" xlink:title=\"urn:x-wiley:14793261:media:vec12410:vec12410-math-0001\"\/> IOI for <jats:italic>R<\/jats:italic> was 5.3, for angle was 3.8, and for MA was 1.4; IOI was not assessed for K.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PRIs are appropriate for TEG variables, <jats:italic>R<\/jats:italic>, angle, and MA when interpreting results from individual horses based on calculated IOI values equal to or greater than 1.4. PRIs are likely appropriate when interpreting <jats:italic>K<\/jats:italic>, but IOI could not be calculated for this variable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12410","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T10:57:54Z","timestamp":1445338674000},"page":"80-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Biological variation of thromboelastrography variables in 10 clinically healthy horses"],"prefix":"10.1111","volume":"26","author":[{"given":"Jennifer L.","family":"Scruggs","sequence":"first","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences University of Tennessee  Knoxville TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Flatland","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences University of Tennessee  Knoxville TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Large Animal Clinical Sciences University of Tennessee  Knoxville TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Reed","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and the Office of Information Technology University of Tennessee  Knoxville TN 37996"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.128"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00179.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165x.2012.00473.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1638\/1042-7260(2007)038[0217:SBVOCC]2.0.CO;2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2006.05.003"},{"key":"e_1_2_9_7_1","first-page":"1","volume-title":"Biological Variation: From Principals to Practice","author":"Fraser CG","year":"2001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.04025.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0673.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00387.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408368909106595"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00157.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200005000-00011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00161.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2008.00381.x"},{"issue":"12","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/clinchem\/16.12.1028","article-title":"Biological and analytical components of variation in long\u2010term studies of serum constituents in normal subjects III. 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