{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:19:05Z","timestamp":1782325145325,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe chelation therapy with<jats:sc>d<\/jats:sc>\u2010penicillamine for treatment of zinc toxicosis in a dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 1.5\u2010year\u2010old intact female Maltese dog weighing 2.7 kg was presented with acute, progressive anorexia, lethargy, pigmenturia, and melena. The owner reported that the dog had ingested a hook from a dog leash made of a zinc\u2010based alloy 9 days prior. A blood transfusion was administered and an abdominal radiograph revealed a metal\u2010dense foreign body in the stomach. Laboratory findings revealed a serum zinc concentration of 1845.12 \u03bcg\/dL (reference interval, 70\u2013200 \u03bcg\/dL) and a decreased hematocrit that remained low despite removal of the zinc foreign body. On day 3, another blood transfusion was performed and<jats:sc>d<\/jats:sc>\u2010penicillamine therapy was instituted. After the administration of<jats:sc>d<\/jats:sc>\u2010penicillamine, the clinical signs and hemogram progressively improved and the dog was discharged 2 days later. On day 9 after initial presentation, the hematocrit and platelet values were within normal limits and the serum zinc concentration was 280.16 \u03bcg\/dL.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This case demonstrates the use of<jats:sc>d<\/jats:sc>\u2010penicillamine in the treatment of zinc toxicosis. Serum zinc concentration appeared to decline more rapidly after administration of<jats:sc>d<\/jats:sc>\u2010penicillamine than before chelation therapy. This is the first report to evaluate serial serum zinc concentrations before and during chelation therapy with<jats:sc>d<\/jats:sc>\u2010penicillamine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12414","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T20:17:29Z","timestamp":1448050649000},"page":"825-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of zinc toxicosis in a dog with chelation using<scp>d<\/scp>\u2010penicillamine"],"prefix":"10.1111","volume":"26","author":[{"given":"Ye\u2010Rin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine, Konkuk University Seoul 143\u2013701 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Hee","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine, Konkuk University Seoul 143\u2013701 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Myung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine, Konkuk University Seoul 143\u2013701 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00418.x"},{"issue":"9","key":"e_1_2_6_3_1","first-page":"712","article-title":"Zinc toxicosis in small animals","volume":"24","author":"Cahill\u2010Morasco R","year":"2002","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_6_4_1","first-page":"204","volume-title":"Osweiler. 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