{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:59:39Z","timestamp":1780077579476,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the occurrence of hypokalemia, metabolic acidosis, and suspected renal tubular acidosis associated with the administration of topical ophthalmic carbonic anhydrase inhibitor (CAI) in a cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 2\u2010year\u2010old, 5.3 kg, male, castrated, domestic short\u2010haired cat developed hyporexia 6 weeks after starting topical ophthalmic dorzolamide 2% therapy for treatment of ocular hypertension. Two weeks later, the cat was evaluated for severe weakness, cervical ventroflexion, and anorexia. Plasma electrolyte and acid\u2013base measurement revealed hypokalemia (K<jats:sup>+<\/jats:sup> = 2.9 mmol\/L; reference interval 3.8\u20135.4 mmol\/L) and metabolic acidosis (plasma HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> = 9.8 mmol\/L; reference interval 15\u201323 mmol\/L) in the presence of a urine pH of 7.5 (reference interval 6.5\u20137.5). The pH abnormalities were consistent with a renal tubular acidosis. Clinical and biochemical abnormalities resolved with short\u2010term supportive care, potassium supplementation, and discontinuation of dorzolamide therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This is the first report of hypokalemia and metabolic acidosis associated with topical CAI therapy in a cat.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12417","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T20:03:49Z","timestamp":1448309029000},"page":"870-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypokalemia and suspected renal tubular acidosis associated with topical carbonic anhydrase inhibitor therapy in a cat"],"prefix":"10.1111","volume":"26","author":[{"given":"Charlotte E.","family":"Thiessen","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University  Ames IA 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle L.","family":"Tofflemire","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University  Ames IA 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Makielski","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University  Ames IA 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Ben\u2010Shlomo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University  Ames IA 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. David","family":"Whitley","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University  Ames IA 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Allbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University  Ames IA 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241030-00004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00053-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.7.1074"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1993.1100"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-163949-6\/50008-4"},{"key":"e_1_2_6_7_1","first-page":"2125","volume-title":"Diseases of the Kidney and Urinary Tract","author":"Schrier RW.","year":"2007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5216.2001.00202.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2001.00169.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91421-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91045-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00912.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200017060-00005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.859"},{"key":"e_1_2_6_15_1","first-page":"253","article-title":"Metabolic acid\u2010base disorders. 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