{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:53:14Z","timestamp":1770753194970,"version":"3.50.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To measure platelet closure time (PCT) in dogs during controlled hemorrhagic shock and after fluid resuscitation with hydroxyethyl starch (HES) 130\/0.4 or 0.9% sodium chloride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Experimental interventional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University veterinary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Eleven healthy Greyhounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Dogs were anesthetized and had 48 mL\/kg of blood removed to induce hemorrhagic shock. Dogs received 20 mL\/kg of HES 130\/0.4 (<jats:italic>n<\/jats:italic>= 6) or 80 mL\/kg of 0.9% sodium chloride (NaCl;<jats:italic>n<\/jats:italic>= 5) intravenously over 20 minutes. PCT was measured using the Platelet Function Analyzer\u2010100 with collagen and adenosine\u2010diphosphate cartridges at: T0 = 60 minutes after induction of anesthesia prior to hemorrhage, T1 = during hemorrhagic shock, and T2 = 40 minutes after completion of fluid bolus. Packed cell volume and platelet count were concurrently measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement and Main Results<\/jats:title><jats:p>Hemorrhagic shock did not significantly change PCT, with no difference between T0 and T1. Both the HES 130\/0.4 and 0.9% NaCl group had a significantly increased mean PCT at T2 of 91.4 seconds (95% CI 69.3\u2013113.4) and 95.5 seconds (95% CI 78.2\u2013112.8), respectively, compared to T1. The magnitude of change was significantly greater for the 0.9% NaCl group than the HES 130\/0.4 group. There was no difference in the magnitude of change in PCV and platelet count between the 2 groups. The PCV and platelet count were &gt;25% and &gt;100,000\/\u03bcL, respectively, in all dogs, except for dogs in the HES 130\/0.4 group at T2 where platelet counts were &lt;100,000\/\u03bcL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Controlled hemorrhagic shock in Greyhounds under anesthesia did not cause a significant change in PCT. Both HES 130\/0.4 and 0.9% NaCl administration after induction of shock increased PCT. These results do not support that HES 130\/0.4 causes relevant platelet dysfunction beyond hemodilution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12468","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T21:13:10Z","timestamp":1458681190000},"page":"509-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Platelet closure time in anesthetized Greyhounds with hemorrhagic shock treated with hydroxyethyl starch 130\/0.4 or 0.9% sodium chloride infusions"],"prefix":"10.1111","volume":"26","author":[{"given":"Duana","family":"McBride","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Service, The Royal Veterinary College University of London North Mymms Hertfordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Hosgood","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Service, 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