{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:32:15Z","timestamp":1762079535698},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine changes in blood granulocyte counts and in plasma myeloperoxidase (MPO) and elastase (ELT) concentrations in surgical colic cases, and to determine the relationship between these changes and the surgical procedure performed, occurrence of postoperative ileus, and final outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective clinical study conducted over a 12\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010three horses undergoing emergency laparotomy and surviving at least 12 hours postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Blood samples were taken before surgery, during surgery, at the recovery from anesthesia, and then serially until the 150th hour after the first blood sampling. Granulocyte counts were performed by an automated cell hematology analyzer. Specific ELISAs were performed for the MPO and ELT measurements. Mixed models were used to compare the time\u2010trends of the 3 parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Taking all horses together, the time\u2010trends of MPO and ELT were not significantly different from each other, but they were significantly different from the granulocyte time\u2010trend. The type of surgical procedure did not influence the time\u2010trends of the 3 parameters. Significant changes in the granulocyte time\u2010trends were associated with postoperative ileus and outcome. Significant changes in the MPO time\u2010trends were associated with outcome. The ELT time\u2010trends were not influenced by ileus or outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Granulocyte counts and MPO change over time and are related to the severity of the inflammatory reaction in surgical colic cases. These time\u2010trends may allow evaluation of treatment efficacy in an effort to modulate excessive granulocyte activation and degranulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12481","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T01:33:54Z","timestamp":1462412034000},"page":"541-548","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of systemic inflammation by time\u2010trends of blood granulocyte count and plasma myeloperoxidase and elastase concentrations following colic surgery in horses"],"prefix":"10.1111","volume":"26","author":[{"given":"Alexandra","family":"Salciccia","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Companion Animals and Horses University of Li\u00e8ge Li\u00e8ge 4000 Belgium"},{"name":"the Center for Oxygen Research and Development University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Grulke","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Companion Animals and Horses University of Li\u00e8ge Li\u00e8ge 4000 Belgium"},{"name":"the Center for Oxygen Research and Development University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffroy","family":"de la Rebi\u00e8re de Pouyade","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Companion Animals and Horses University of Li\u00e8ge Li\u00e8ge 4000 Belgium"},{"name":"the Center for Oxygen Research and Development University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Franck","sequence":"additional","affiliation":[{"name":"the Center for Oxygen Research and Development University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Detilleux","sequence":"additional","affiliation":[{"name":"the Faculty of Veterinary Medicine, Quantitative Genetics University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Serteyn","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Companion Animals and Horses University of Li\u00e8ge Li\u00e8ge 4000 Belgium"},{"name":"the Center for Oxygen Research and Development University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Sandersen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Companion Animals and Horses University of Li\u00e8ge Li\u00e8ge 4000 Belgium"},{"name":"the Center for Oxygen Research and Development University of Li\u00e8ge Li\u00e8ge 4000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006408522233"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00593.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-6226(99)00126-8"},{"issue":"9","key":"e_1_2_8_5_1","first-page":"800","article-title":"Causes of gastrointestinal colic in horses in western Canada: 604 cases (1992 to 2002)","volume":"46","author":"Abutarbush SM","year":"2005","journal-title":"Can Vet J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.9.1069"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"296","article-title":"Survival and complication rates in 300 horses undergoing surgical treatment of colic","volume":"37","author":"Mair TS","year":"2005","journal-title":"Part 1: short\u2010term survival following a single laparotomy. Equine Vet J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-56-20"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-56-38"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776117791"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054529364"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2010.00700.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776117845"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054529472"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1998.tb04515.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1976.tb05440.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.10.024"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.1.81"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775467234"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1420"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.01.010"},{"issue":"5","key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1182\/blood.V83.5.1398.1398","article-title":"Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome","volume":"83","author":"Simms HH","year":"1994","journal-title":"Blood"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0673.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.10.1162"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.6.885"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101503"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.02.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900064"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2012.12.004"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01303172"},{"issue":"4","key":"e_1_2_8_31_1","first-page":"291","article-title":"Myeloperoxidase concentration in bronchoalveolar lavage fluid from healthy horses and those with recurrent airway obstruction","volume":"70","author":"Art T","year":"2006","journal-title":"Can J Vet Res"},{"issue":"5","key":"e_1_2_8_32_1","first-page":"H1017","article-title":"Endotoxemia and neutrophil activation in vivo","volume":"254","author":"Grisham MB","year":"1988","journal-title":"Am J Physiol"},{"issue":"2","key":"e_1_2_8_33_1","first-page":"142","article-title":"Plasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results","volume":"63","author":"Grulke S","year":"1999","journal-title":"Can J Vet Res"},{"issue":"1","key":"e_1_2_8_34_1","first-page":"37","article-title":"Myeloperoxidase assay in plasma and peritoneal fluid of horses with gastrointestinal disease","volume":"72","author":"Grulke S","year":"2008","journal-title":"Can J Vet Res"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.10.023"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.72"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2007.tb00202.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700502"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2008.03.004"},{"issue":"5","key":"e_1_2_8_40_1","first-page":"e28","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. 1992","volume":"136","author":"Bone RC","year":"2009","journal-title":"Chest"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054406856"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.1364"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.12.010"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69005-3"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.08.033"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.01.002"},{"issue":"12","key":"e_1_2_8_47_1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.2460\/javma.1994.205.12.1748","article-title":"Evaluation of factors associated with postoperative ileus in horses: 31 cases (1990\u20131992)","volume":"205","author":"Blikslager AT","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2000.tb05333.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199811000-00004"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2012.01.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.09.001"},{"issue":"2","key":"e_1_2_8_52_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-5223(19)36564-X","article-title":"Myeloperoxidase and elastase as markers of leukocyte activation during cardiopulmonary bypass in humans","volume":"102","author":"Faymonville ME","year":"1991","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(98)00192-5"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvec.12481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvec.12481","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.12481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T06:20:45Z","timestamp":1718518845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.12481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/vec.12481"],"URL":"https:\/\/doi.org\/10.1111\/vec.12481","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,4]]},"assertion":[{"value":"2014-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}