{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:34:16Z","timestamp":1778279656472,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the successful treatment of loperamide toxicosis in a dog using intravenous lipid emulsion (ILE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>An 8\u2010month\u2010old male neutered Rough Collie weighing 20.0 kg was given a total dose of 0.75 mg\/kg loperamide over 3 days as treatment for diarrhea. The dog was subsequently evaluated for signs of dull mentation, anxiety, ptyalism and ataxia, thought to be a result of loperamide intoxication. The dog was treated with a 1.5 mL\/kg IV bolus of 20% ILE solution followed by 0.25 mL\/kg\/min of the same solution for 2 hours. The dog's mentation improved rapidly following ILE infusion, and he was neurologically normal 3 hours after initiation of ILE treatment. The dog was subsequently found to be homozygous for the ATP\u2010binding cassette (ABC) transporter gene (ABCB1\u20101\u2206) mutation. There were no adverse effects noted during or following ILE infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>ILE was successful in the treatment of loperamide toxicosis in a Collie with the ABCB1\u20101\u2206 mutation. ILE may be of benefit for treatment of other intoxications in dogs with ABCB1\u20101\u0394 mutations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12562","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T20:13:09Z","timestamp":1482178389000},"page":"357-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1\u20101\u2206 mutation"],"prefix":"10.1111","volume":"27","author":[{"given":"Whitney M.","family":"Long","sequence":"first","affiliation":[{"name":"Angell Animal Medical Center  350 South Huntington Avenue Boston MA 02130"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia B.","family":"Sinnott","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center  350 South Huntington Avenue Boston MA 02130"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiko","family":"Bracker","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center  350 South Huntington Avenue Boston MA 02130"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Thomas","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center  350 South Huntington Avenue Boston MA 02130"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200111000-00012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.479"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.6.921"},{"key":"e_1_2_6_5_1","unstructured":"Washington State University Veterinary Clinical Pharmacology Lab. 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