{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:53:42Z","timestamp":1770224022589,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess abnormalities in concentrations of cardiac troponin I<jats:bold>(<\/jats:bold>cTnI<jats:bold>),<\/jats:bold>lactate, and N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) in relation to arrhythmias, echocardiographic measurements, and survival in dogs with gastric dilatation volvulus (GDV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010two dogs with naturally occurring GDV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Samples<\/jats:title><jats:p>Concentrations of cTnI<jats:bold>,<\/jats:bold>plasma lactate, and NT\u2010proBNP were recorded at presentation to the emergency room, the time closest to echocardiography, and the highest recorded concentrations during hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Cardiac rhythms were categorized on a 0\u20134 scale (0 = no ventricular premature complexes [VPCs], 1 = single VPCs, 2 = bigeminy or trigeminy, 3 = couplets or triplets, and 4 = R\u2010on\u2010T phenomenon or ventricular tachycardia). Echocardiography was performed 6\u201318 hours postoperatively. Fifteen dogs had ventricular arrhythmias during hospitalization (Grade 1 [<jats:italic>n<\/jats:italic>= 9], Grade 4 [<jats:italic>n<\/jats:italic>= 6]). The highest recorded cTnI concentration was significantly higher in the dogs with Grade 4 (<jats:italic>P<\/jats:italic>= 0.002) or Grade 1 (<jats:italic>P<\/jats:italic>= 0.001) arrhythmias compared to dogs without arrhythmias. Plasma lactate was significantly correlated with left ventricular internal diameter in diastole (<jats:italic>r<\/jats:italic>= \u22120.52,<jats:italic>P<\/jats:italic>= 0.01) and systole (<jats:italic>r<\/jats:italic>= \u22120.57,<jats:italic>P<\/jats:italic>= 0.006), left ventricular free wall in diastole (LWDd,<jats:italic>r<\/jats:italic>= 0.59,<jats:italic>P<\/jats:italic>= 0.004), and interventricular septal thickness in diastole (IVDs,<jats:italic>r<\/jats:italic>= 0.65,<jats:italic>P<\/jats:italic>= 0.001). Dogs that did not survive to 1 week postdischarge (3\/22) had a significantly thicker LVWd (<jats:italic>P<\/jats:italic>= 0.04) and IVSd (<jats:italic>P<\/jats:italic>= 0.05), and received significantly less fluids in the first 24 (<jats:italic>P<\/jats:italic>= 0.02) and 48 hours (<jats:italic>P<\/jats:italic>= 0.03) of hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Concentrations of cTnI and NT\u2010proBNP increased during hospitalization, but only cTnI concentrations were significantly higher in dogs with a higher arrhythmia grade. Additional research on the potential role of serial measurement of biomarkers in dogs with GDV is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12667","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T16:20:17Z","timestamp":1506615617000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of echocardiography and cardiac biomarker concentrations in dogs with gastric dilatation volvulus"],"prefix":"10.1111","volume":"27","author":[{"given":"Brent D.","family":"Aona","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts University 200 Westboro Road North Grafton MA 01536"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Rush","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts University 200 Westboro Road North Grafton MA 01536"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-8930","authenticated-orcid":false,"given":"Elizabeth A.","family":"Rozanski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts University 200 Westboro Road North Grafton MA 01536"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts University 200 Westboro Road North Grafton MA 01536"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-9783","authenticated-orcid":false,"given":"Claire R.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cummings School of Veterinary Medicine at Tufts 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