{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:19Z","timestamp":1787016139881,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate C\u2010reactive protein (CRP), interleukin 6 (IL\u20106), and tumor necrosis factor alpha (TNF\u2010\u03b1) kinetics in dogs with a systemic inflammatory response syndrome (SIRS) presented to an emergency service. We hypothesized serum CRP concentrations would increase and vary during hospitalization, and would correlate with plasma IL\u20106 and TNF\u2010\u03b1 concentrations, vary in magnitude according to the underlying disease, and predict survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, observational, clinical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty\u2010nine dogs with SIRS weighing over 5 kg who could tolerate the blood sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Serum and plasma were collected (and stored at \u201380\u00b0C) at presentation (T0), after 6 (T6), 12 (T12), 24 (T24), and 72 (T72) hours, and at a follow\u2010up visit at least 1 month after discharge (T1m). Underlying diseases were categorized as infection (I), neoplasia (N), trauma (T), gastric\u2010dilation and volvulus (GDV), other gastrointestinal (GI), renal (R), and miscellaneous (M) disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Serum CRP concentration was measured using a canine\u2010specific immunoturbidimetric assay. Biologically active plasma IL\u20106 and TNF\u2010\u03b1 concentrations were assessed using bioassays. Forty\u2010four dogs survived, 8 died, and 17 were euthanized. Nineteen dogs had follow\u2010up visits. At T0, serum CRP concentration was above the reference interval in 73.1% (49\/67), and was within the reference interval (0\u2013141.9 nmol\/L) throughout hospitalization in only 6% (4\/67). Serum CRP concentrations were significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) at T0 (882.9 \u00b1 1082.9 nmol\/L) and at all time points during hospitalization (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) compared to T1m, with highest concentrations observed at T24 (906. 7 \u00b1 859.0 nmol\/L). At T1m, serum CRP concentrations were within the reference interval (22.9 \u00b1 42.9 nmol\/L) in 95% (18\/19) of dogs. Logarithmic concentrations of serum CRP and plasma IL\u20106 were significantly correlated (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001,\n                      <jats:italic>r<\/jats:italic>\n                      = 0.479). None of the measured cytokines were associated with disease category or outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum CRP concentration is increased in dogs with SIRS, and decreases during treatment and hospitalization. Serum CRP, plasma IL\u20106, and plasma TNF\u2010\u03b1 concentrations cannot predict outcome in dogs with SIRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.12685","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T09:32:44Z","timestamp":1513157564000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Inflammatory cytokine and C\u2010reactive protein concentrations in dogs with systemic inflammatory response syndrome"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-1002","authenticated-orcid":false,"given":"Kris","family":"Gommeren","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge 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