{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:06:01Z","timestamp":1777799161678,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the use of therapeutic plasma exchange (TPE) in a dog with carprofen toxicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>A 6\u2010year\u2010old female neutered Bichon Frise weighing 6.9 kg was examined after it had ingested 72 mg\/kg carprofen. Mild dehydration without azotemia and with a urine specific gravity of 1.050 was noted at presentation. Treatment consisted of induction of emesis, symptomatic medical therapy, and TPE. The TPE achieved 1.5 plasma volume exchanges over 3 hours. Blood samples and effluent samples were collected every 30 minutes during TPE and additional blood samples were collected 11 and 35 hours after treatment. Carprofen concentrations in these samples were determined by high\u2010pressure liquid chromatography. A 51% reduction in serum carprofen concentration was achieved following TPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This report describes the successful reduction of plasma carprofen concentration in a dog using TPE. Although recent studies suggest that this particular dog may not have received a toxic dose, a 51% reduction of plasma carprofen concentration was achieved over 180 minutes, and TPE may be beneficial for treatment of dogs that have ingested higher doses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12729","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T16:25:12Z","timestamp":1528907112000},"page":"356-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Treatment of carprofen overdose with therapeutic plasma exchange in a dog"],"prefix":"10.1111","volume":"28","author":[{"given":"Astrid B.","family":"Kjaergaard","sequence":"first","affiliation":[{"name":"Section of Companion Animal Medicine, Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Large Animal Analysis Laboratory, College of Veterinary Medicine North Carolina State University  Raleigh NC 27613"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Acierno","sequence":"additional","affiliation":[{"name":"Section of Companion Animal Medicine, Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge LA 70803"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102834"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem070"},{"key":"e_1_2_6_4_1","unstructured":"NADA #141\u2010111 Rimadyl FDA approval.2013."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00617.x"},{"issue":"2","key":"e_1_2_6_6_1","first-page":"170","article-title":"Enantioselectivity of the enterohepatic recycling of carprofen in the dog","volume":"26","author":"Priymenko N","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510110704"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1990.tb00510.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600691104"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.01.003"},{"key":"e_1_2_6_11_1","first-page":"687","volume-title":"Small Animal Toxicology","author":"Talcott PA"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102107"},{"key":"e_1_2_6_13_1","article-title":"Risk factors for carprofen toxicosis","author":"Volmer P","year":"2009","journal-title":"Toxicology Brief"},{"issue":"7","key":"e_1_2_6_14_1","first-page":"325","article-title":"Managing acute carprofen toxicosis in dogs and cats","volume":"104","author":"Volmer P","year":"2009","journal-title":"Vet Med"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12305"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.7.3797920"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01033.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00431.x"},{"issue":"2","key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5455\/OVJ.2015.v5.i2.p108","article-title":"Double filtration plasmapheresis in a dog with multiple myeloma and hyperviscosity syndrome","volume":"5","author":"Lippi I","year":"2015","journal-title":"Open Vet J"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12026"},{"key":"e_1_2_6_21_1","unstructured":"American Academy of Veterinary Pharmacology and Therapeutics.Carprofen (Veterinary \u2014 Systemic).in The United State Pharmacopeial Convention 2007; 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