{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:54:11Z","timestamp":1768622051819,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007456","name":"Canine Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001799","name":"Murdoch University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective<\/jats:bold>: To investigate the association between synthetic colloids and biomarkers of acute kidney injury (AKI) in dogs with hemorrhagic shock.<\/jats:p><jats:p><jats:bold>Design<\/jats:bold>: Experimental interventional study.<\/jats:p><jats:p><jats:bold>Setting<\/jats:bold>: University.<\/jats:p><jats:p><jats:bold>Animals<\/jats:bold>: Twenty\u2010four healthy ex\u2010racing Greyhounds.<\/jats:p><jats:p><jats:bold>Interventions<\/jats:bold>: Anesthetized Greyhounds subjected to hemorrhage for 60\u00a0min were resuscitated with 20\u00a0mL\/kg of fresh whole blood (FWB), 6% hydroxyethyl starch (HES) 130\/0.4, 4% succinylated gelatin (GELO), or 80\u00a0mL\/kg of isotonic crystalloid (CRYST) over 20\u00a0min (<jats:italic>n<\/jats:italic>\u00a0=\u00a06 per treatment). Concentrations of biomarkers of AKI were measured at baseline, end of hemorrhage, and at 40 (T60), 100 (T120), and 160 (T180) min after fluid bolus. Biomarkers included neutrophil gelatinase\u2010associated lipocalin in urine and serum (uNGAL; sNGAL), and urine cystatin C (uCYSC), kidney injury molecule\u20101 (uKIM), clusterin (uCLUST), osteopontin, gamma\u2010glutamyl transferase, monocyte chemoattractant protein\u20101 (uMCP), interleukin\u20106, interleukin\u20108, protein (uPROT), hyaluronan, and F<jats:sub>2<\/jats:sub>\u2010isoprostanes. Renal histology was scored for tubular injury and microvesiculation. Biomarker fold\u2010change from baseline was compared between groups using mixed effects models (Bonferroni\u2013Holm corrected <jats:italic>P<\/jats:italic>&lt;0.05). Frequencies of histology scores were compared by Fisher's exact test.<\/jats:p><jats:p><jats:bold>Measurements and main results<\/jats:bold>: In dogs treated with GELO, uNGAL fold\u2010change was markedly greater compared with all other groups at T60, T120, and T180 (all <jats:italic>P<\/jats:italic>&lt;0.001), and uCYSC was greater at T60 compared with CRYST (<jats:italic>P<\/jats:italic>&lt;0.001), and at T120 and T180 compared with all other groups (all <jats:italic>P<\/jats:italic>&lt;0.001). Smaller, albeit significant, between\u2010group differences in uKIM, uCLUST, uMCP, and urine protein concentration were observed across the FWB, GELO, and HES groups, compared with CRYST. The GELO group more frequently had marked tubular microvesiculation than the other groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) although tubular injury scores were comparable.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: In dogs with hemorrhagic shock, GELO was associated with greater magnitude increases in urine biomarkers of AKI and more frequent marked tubular microvesiculation, compared with FWB, CRYST, and HES.<\/jats:p>","DOI":"10.1111\/vec.12814","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T06:33:33Z","timestamp":1550212413000},"page":"132-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of biomarkers of kidney injury following 4% succinylated gelatin and 6% hydroxyethyl starch 130\/0.4 administration in a canine hemorrhagic shock model"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-2148","authenticated-orcid":false,"given":"Corrin J.","family":"Boyd","sequence":"first","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Claus","sequence":"additional","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthea L.","family":"Raisis","sequence":"additional","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Bosio","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research in Emergency Medicine Harry Perkins Institute of Medical Research  Perth WA Australia"},{"name":"Emergency Medicine University of Western Australia  WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Hosgood","sequence":"additional","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Nabity","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology Texas A&amp;M University College Station  TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Mori","sequence":"additional","affiliation":[{"name":"Medical School Royal Perth Hospital Unit University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Barden","sequence":"additional","affiliation":[{"name":"Medical School Royal Perth Hospital Unit University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-9783","authenticated-orcid":false,"given":"Claire R.","family":"Sharp","sequence":"additional","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-2849","authenticated-orcid":false,"given":"Lisa","family":"Smart","sequence":"additional","affiliation":[{"name":"School of Veterinary and Life Sciences Murdoch University  Perth WA Australia"},{"name":"Centre for Clinical Research in Emergency Medicine Harry Perkins Institute of Medical Research  Perth WA Australia"},{"name":"Emergency Medicine University of Western Australia  WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1265-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04211-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070716"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318212096a"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318258fee7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209759"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204242"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12412"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14645"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12483"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2017.00140"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.04.011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11161"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31827e554c"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1704-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093863"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.02.034"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0797-4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2018.00279"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.05.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201511-2281OC"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.24441"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7592-1_21"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.165"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.4.419"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148043"},{"key":"e_1_2_10_30_1","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"1979","author":"Holm S","journal-title":"Scand J Stat"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12647"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.555"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200908-1214OC"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13989"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12180"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14853"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199816020-00008"},{"key":"e_1_2_10_38_1","first-page":"597","article-title":"Meaning of arterio\u2010venous PCO2 difference in circulatory shock","volume":"72","author":"Lamia B","year":"2006","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080894"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.17.1032"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.10.044"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3156-9"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92345-T"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07588-5"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12311"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00980110"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82217-7"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvec.12814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.12814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.12814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.12814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:26:32Z","timestamp":1694427992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.12814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,14]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/vec.12814"],"URL":"https:\/\/doi.org\/10.1111\/vec.12814","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,14]]},"assertion":[{"value":"2018-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}