{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:00:56Z","timestamp":1763748056007,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical signs, clinicopathologic abnormalities, treatment, and outcome after IV administration of polyethylene glycol 3350 (PEG3350) in a cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A cat was inadvertently administered 6 g\/kg of PEG3350 in electrolyte solution, IV, resulting in severe hypernatremia (203\u00a0mmol\/L), diffuse encephalopathy, hemolysis, and moderate azotemia. The hemolysis and acute kidney injury observed immediately following PEG3350 administration resolved with supportive care. Administration of IV and oral electrolyte\u2010free water slowly corrected the hypernatremia and the neurologic signs subsequently improved. Complete resolution of clinical signs was documented one month following hospital discharge. The PEG3350 concentrations in serum, plasma, and urine samples confirmed toxic exposure to PEG3350. Efficacy of treatment was evident by decreasing concentrations of PEG3350 in serum after the first 24 hours of treatment. Renal elimination of PEG3350 was significant and PEG3350 was still detected in the urine 17 days after exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>New Information Provided<\/jats:title><jats:p>This is the first report to describe the clinical signs and clinicopathologic abnormalities in a cat intoxicated with IV PEG3350. Potential pathophysiologic mechanisms are discussed, and the successful supportive medical treatment is outlined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12888","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T07:39:40Z","timestamp":1567237180000},"page":"690-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-6268","authenticated-orcid":false,"given":"Sabrina N.","family":"Hoehne","sequence":"first","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey J.","family":"Kohen","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Puschner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences School of Veterinary Medicine University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Gennity","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences School of Veterinary Medicine University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P.","family":"Hagley","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate S.","family":"Farrell","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Unger","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Cagle","sequence":"additional","affiliation":[{"name":"Center for Comparative Respiratory Biology and Medicine University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-7817","authenticated-orcid":false,"given":"Karl E.","family":"Jandrey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences School of Veterinary Medicine University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,31]]},"reference":[{"volume-title":"Textbook of Veterinary Internal Medicine","year":"1975","author":"Greene R","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03727.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.05.017"},{"key":"e_1_2_6_5_1","first-page":"153","article-title":"Absorption of polyethylene glycol after administration of a PEG\u2010electrolyte lavage solution","volume":"5","author":"DiPiro JT","year":"1986","journal-title":"Clin Pharm"},{"key":"e_1_2_6_6_1","first-page":"3817","volume-title":"Patty's Industrial Hygiene and Toxicology","author":"Clayton GD","year":"1982"},{"key":"e_1_2_6_7_1","first-page":"293","article-title":"Some pharmacological actions of polypropylene glycols of average molecular weight 400, 750, 1200 and 2000","volume":"103","author":"Shideman FE","year":"1951","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E046"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90312-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300861"},{"key":"e_1_2_6_11_1","first-page":"863","article-title":"[Electrolytic disturbances and colonoscopy: bowel lavage solutions, age and procedure]","volume":"95","author":"Mar\u00edn Gabriel JC","year":"2003","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4266\/kjccm.2015.30.1.56"},{"key":"e_1_2_6_13_1","unstructured":"ChakrabortiTK.Department of health and human serviced public health service food and drug administration center for drug evaluation and research; pharmacology\/toxicology review and evaluation miralax (polyethylene glycol 3350 powder for oral solution).2005Dec. 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