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In groups 2\u20104, blood samples were collected for leukocyte, platelet, and erythrocyte counts 24\u00a0h after venom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Rats injected with venom alone (Group 1) developed signs of neurotoxicity and ataxia and died in 9.0 \u00b1 0.43\u00a0h but showed no changes in leukocyte or erythrocyte counts. In contrast, there were no deaths in groups 2\u20104. The lack of deaths in Groups 3 and 4 indicated that antivenom and hemoperfusion, respectively, protected against the lethal effects of the venom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hemoperfusion with a double\u2010action hemoperfusion cartridge capable of protein adsorption and precipitation protected rats against <jats:italic>C. d. terrificus<\/jats:italic> venom.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12949","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T09:59:55Z","timestamp":1582970395000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Experimental model for removal of snake venom via hemoperfusion in rats"],"prefix":"10.1111","volume":"30","author":[{"given":"Maximilian Estevan","family":"Oliveira","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program in Pharmaceutical Sciences University of 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