{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:00:15Z","timestamp":1791075615500,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the incidence of tranexamic acid (TXA)\u2010induced nausea and vomiting after the prophylactic use of 2 antiemetics, ondansetron and maropitant, compared with saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, blinded, placebo\u2010controlled, randomized, crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University research facility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Eight adult, purpose\u2010bred Beagles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Dogs received 3 treatments on 3 occasions with a 3\u2010week washout period. Either maropitant (1\u00a0mg\/kg), ondansetron (0.2\u00a0mg\/kg), or saline solution was given intravenously in equal volumes, followed 10 minutes later by 50\u00a0mg\/kg IV TXA. A blinded observer evaluated the dogs for signs of vomiting and nausea for 30 minutes. The severity of nausea was assessed with a visual analog scale (VAS) and recorded at baseline before TXA, and at the end of 3 observational periods: 0\u20135, 5\u201315, and 15\u201330 minutes after TXA. A generalized linear mixed effect model was used to assess for group and period effects. Statistical significance was set at <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/vec12954-math-0001.png\" xlink:title=\"urn:x-wiley:14793261:media:vec12954:vec12954-math-0001\"\/>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and main results<\/jats:title><jats:p>None of the dogs vomited after maropitant. Emesis occurred in 5 out of 8 dogs (62.5%), a median (range) of 1 time (1\u20132) after ondansetron and 1 time (1\u20133) after saline. There was a significant effect on vomiting of maropitant against saline (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) but not for ondansetron against saline (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.53). The highest nausea VASs were recorded during the first 5 minutes after TXA with a significant reduction of VAS variability in the maropitant group (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003). The effect of maropitant and ondansetron against saline on the severity of nausea was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.069).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The neurokinin 1 receptor antagonist maropitant at the dose used, administered IV 10 minutes before 50\u00a0mg\/kg TXA, was effective in preventing vomiting compared with ondansetron and placebo. Our results support the prophylactic IV administration of maropitant in dogs that are scheduled to receive TXA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12954","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T13:49:56Z","timestamp":1591710596000},"page":"436-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prospective, controlled, blinded, randomized crossover trial evaluating the effect of maropitant versus ondansetron on inhibiting tranexamic acid\u2010evoked emesis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-6957","authenticated-orcid":false,"given":"Marta E.","family":"Kantyka","sequence":"first","affiliation":[{"name":"Section of Anesthesiology Department of Clinical Diagnostics and Services Vetsuisse Faculty of the University of Zurich  Zurich 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