{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:25:05Z","timestamp":1762431905585,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a serious adverse event of gastrointestinal obstruction requiring surgery following routine administration of multiple doses of activated charcoal (AC) granules, which were prescribed for carprofen toxicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 2\u2010year\u2010old female neutered Airedale Terrier presented for ingestion of 207\u00a0mg\/kg of carprofen. Decontamination was initiated with apomorphine to induce emesis. Along with additional supportive care, the dog received an initial dose of\u00a075\u00a0mL of AC suspension containing sorbitol by mouth (15.6\u00a0g of AC, or 0.6\u00a0g\/kg), followed by 50\u00a0g of AC granules every 8\u00a0hours for 4 additional doses. While hospitalized, the dog experienced clinical signs, including vomiting and black diarrhea, as well as bloodwork changes including mild to moderate elevations in kidney and liver enzymes. Given clinical improvement after 72\u00a0hours of hospitalization, the patient was discharged for monitoring and ongoing care at home.\u00a0Two days later, the patient presented again for nausea, dark diarrhea with frank blood, and panting. Abdominal ultrasound showed findings\u00a0suspicious for partially obstructive foreign material or atypical impacted fecal material partially occluding the distal ileum. Despite medical management overnight, recheck ultrasound the following day demonstrated persistent\u00a0obstruction\u00a0with ileal foreign material. Exploratory laparotomy and enterotomy revealed moderate distension and obstruction of the distal ileum with black granular foreign material consistent with charcoal granules. The patient remained in hospital for supportive care for 4 days following the procedure, and all clinical signs were resolved at the time of discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This report documents a serious adverse event of gastrointestinal obstruction associated with routine multidose AC administration, which has been occasionally reported in people but not in dogs. The potential for this complication should be taken into account when prescribing multiple doses of AC granules.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12980","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T08:08:36Z","timestamp":1593072516000},"page":"461-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gastrointestinal obstruction secondary to activated charcoal granule impaction in a dog"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8536-2443","authenticated-orcid":false,"given":"Kate S.","family":"Farrell","sequence":"first","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-0706","authenticated-orcid":false,"given":"Jamie M.","family":"Burkitt\u2010Creedon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences School of Veterinary Medicine University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-0006","authenticated-orcid":false,"given":"Laura G.","family":"Osborne","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin A.","family":"Gibson","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Massie","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California  Davis CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1081\/CLT-51867"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"731","article-title":"American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Position statement and practice guidelines on the use of multi\u2010dose activated charcoal in the treatment of acute poisoning","volume":"37","year":"1999","journal-title":"Clin. 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