{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:52:36Z","timestamp":1778496756844,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a complex case involving the management of a dog with von Willebrand disease (vWD), active ehrlichiosis infection, nonregenerative anemia, and blood type incompatibility related to the<jats:italic>Dal<\/jats:italic>antigen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 13\u2010week\u2010oldintact male Doberman Pinscher weighing 7.2\u00a0kg was presented to the emergency service for a previous hemorrhaging event and progressive nonregenerative anemia. The dog had received a fresh whole blood transfusion 8 days prior to presentation due to severe anemia. Upon presentation, the puppy was tachycardic, and his mucous membranes were pale. A CBC revealed a nonregenerative anemia with a PCV of 0.11 L\/L (11%). von Willebrand factor deficiency was suspected and later confirmed. The dog's blood type was dog erythrocyte antigen (DEA) 1 positive, but cross\u2010matching to 4 RBC units, both DEA 1 positive and negative, failed to yield any compatible units. Antibody against a possible<jats:italic>Dal<\/jats:italic>RBC antigen was suspected, and 11 blood donors (Dalmatians and Dobermans) were cross\u2010matched to find 2 compatible donors. After an uneventful fresh whole blood transfusion, a bone marrow biopsy revealed a hypocellular bone marrow and erythroid hypoplasia. A SNAP4DxPlus test and subsequent polymerase chain reaction (PCR) testing were positive for<jats:italic>Ehrlichia ewingii<\/jats:italic>and<jats:italic>E. canis<\/jats:italic>. Treatment with doxycycline was started, and the PCV was 0.17 L\/L (17%) at discharge. At the 1\u2010week follow\u2010up, the PCV was 0.24 L\/L (24%), and the puppy was doing well.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This is a unique case of a dog presenting with several challenging disorders, including vWD resulting in hemorrhage, ehrlichiosis potentially contributing to a nonregenerative anemia, and a blood type incompatibility due to the<jats:italic>Dal<\/jats:italic>antigen. Doberman Pinschers have a high prevalence of vWD\u2010 and<jats:italic>Dal<\/jats:italic>\u2010negative phenotype, which emphasizes the value of cross\u2010matching and the recognition of antigen prevalence in specific breeds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13015","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:01:49Z","timestamp":1603969309000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Dal<\/i>\u2010induced red blood cell incompatibilities in a Doberman Pinscher with von Willebrand factor deficiency and ehrlichiosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0690-8410","authenticated-orcid":false,"given":"Andreza","family":"Conti\u2010Patara","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Washington State University Pullman WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-9134","authenticated-orcid":false,"given":"Thandeka R.","family":"Ngwenyama","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Washington State University Pullman WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Washington State University Pullman WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Jane","family":"Wardrop","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Washington State University Pullman WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"9","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.2460\/javma.1995.206.09.1358","article-title":"An acute hemolytic transfusion reaction caused by dog erythrocyte antigen 1.1 incompatibility in a previously sensitized dog","volume":"206","author":"Giger U","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb02961.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14801"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14693"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02340-14"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14735"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"495","article-title":"The blood grouping systems of dogs","volume":"41","author":"Swisher SN","year":"1961","journal-title":"Physical Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00249.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.4.431"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985816688746"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.115"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.250.3.303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12671"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02100.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1700"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15354"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02178.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2008.0184"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2205.152009"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2015.11.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12120"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.02.015"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.13015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T16:18:40Z","timestamp":1723825120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/vec.13015"],"URL":"https:\/\/doi.org\/10.1111\/vec.13015","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"2018-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}