{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:06Z","timestamp":1787016066964,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:00:00Z","timestamp":1606608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the semiquantitative acid\u2013base status of dogs with untreated naturally occurring typical hypoadrenocorticism and to compare this to the status determined by traditional acid\u2013base analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty\u2010three dogs with newly diagnosed typical hypoadrenocorticism between 2000 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and main results<\/jats:title>\n                    <jats:p>\n                      Dogs were included if they had newly diagnosed hypoadrenocorticism, post\u2010ACTH stimulation serum cortisol concentration\u00a0&lt;2\u00a0\u03bcg\/dL, and blood collected within 6\u00a0hours of presentation for acid\u2013base, electrolyte, and serum biochemical assays. Dogs were excluded if the Na\n                      <jats:sup>+<\/jats:sup>\n                      :K\n                      <jats:sup>+<\/jats:sup>\n                      ratio was\u00a0\u226528 or the dog had received a mineralocorticoid\u2010containing corticosteroid medication within the preceding month. Traditional acid\u2013base analysis identified normal acid\u2013base status in 1 dog, simple respiratory acid\u2013base abnormalities in 2 of 33 dogs, and simple metabolic acidosis in 14 of 33 dogs. A mixed disorder was most common, noted in 16 of 33 dogs. The semiquantitative approach identified metabolic abnormalities in all cases. All dogs had \u22651 acidifying process, and 29 of 33 had both acidifying and alkalinizing processes. Acidosis attributable to excess free water was present in all dogs, and an acidifying phosphate effect was present in 27 of 33. Hyperlactatemia contributed to the acidosis in 8 of 33 dogs, with a median (range) lactate concentration of 1.5\u00a0mmol\/L (13.5\u00a0mg\/dL) (0.3\u20134.2\u00a0mmol\/L [2.7\u201337.8\u00a0mg\/dL]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dogs with untreated Addison's disease have complex acid\u2013base derangements. The semiquantitative approach to acid\u2013base analysis provides greater insight into the underlying mechanisms of metabolic acid\u2013base abnormalities in these dogs, particularly because lactic acidosis appears to be a minor influence in most cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.13016","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T02:49:20Z","timestamp":1606704560000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Semiquantitative acid\u2013base analysis in dogs with typical hypoadrenocorticism"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-0006","authenticated-orcid":false,"given":"Laura G.","family":"Osborne","sequence":"first","affiliation":[{"name":"Small Animal Emergency and Critical Care Western Veterinary Specialist and Emergency Centre, Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-0706","authenticated-orcid":false,"given":"Jamie M.","family":"Burkitt\u2010Creedon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-6695","authenticated-orcid":false,"given":"Steven E.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Hopper","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2460\/javma.1996.208.01.85","article-title":"Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism: 225 cases (1979\u20101993)","volume":"208","author":"Peterson ME","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb02377.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.8.1190"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01933.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.01.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.02.005"},{"key":"e_1_2_8_8_1","first-page":"63","article-title":"Canine hypoadrenocorticism: part I","volume":"51","author":"Klein SC","year":"2010","journal-title":"Can Vet J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2014.10.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0654-3.00023-8"},{"key":"e_1_2_8_11_1","first-page":"163","volume-title":"Clinical Physiology of Acid\u2010Base and Electrolyte Disorders","author":"Rose BD","year":"2001"},{"key":"e_1_2_8_12_1","first-page":"150","volume-title":"Vander's Renal Physiology","author":"Eaton DC","year":"2018"},{"key":"e_1_2_8_13_1","first-page":"888","volume-title":"Clinical Physiology of Acid\u2010Base and Electrolyte Disorders","author":"Rose BD","year":"2001"},{"key":"e_1_2_8_14_1","first-page":"1825","volume-title":"Textbook of Veterinary Internal Medicine","author":"Hess RS","year":"2017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4456-5.00012-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2384-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12214"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2005.04.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2008.00344.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12215"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-008-9037-y"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.9904099"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1496-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-0306-7.00055-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12589"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50036-2"},{"key":"e_1_2_8_27_1","first-page":"525","volume-title":"Clinical Veterinary Advisor. 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