{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:38:05Z","timestamp":1768621085054,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of 6% hydroxyethyl starch 130\/0.4 (HES) and a polyionic isotonic crystalloid (CRYS) on standard coagulation tests and rotational thromboelastometry (ROTEM) in dogs with spontaneous hemoperitoneum (SHP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective randomized open\u2010label clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty\u2010two client\u2010owned dogs presented with SHP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Dogs diagnosed with SHP and hypovolemic shock were randomly allocated to receive HES (10\u00a0mL\/kg, n\u00a0=\u00a022) or CRYS (30\u00a0mL\/kg, n\u00a0=\u00a020) intravenously over 20 minutes for hemodynamic stabilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and main results<\/jats:title><jats:p>Parameters measured before (T<jats:sub>0<\/jats:sub>) and after (T<jats:sub>1<\/jats:sub>) treatment were HCT, platelet counts, prothrombin time, activated partial thromboplastin time, fibrinogen concentrations, and extrinsic activated (EXTEM), intrinsic activated (INTEM), and extrinsic activated with platelet inhibition ROTEM assays. Data were analyzed as absolute values and as the percentage change from T<jats:sub>0<\/jats:sub> to T<jats:sub>1<\/jats:sub>. No significant differences between groups were detected in any variable at T<jats:sub>0<\/jats:sub>, and for HCT, platelet counts, prothrombin time, activated thromboplastin time, and fibrinogen concentrations at T<jats:sub>1<\/jats:sub>. Clot formation time in EXTEM was significantly prolonged (<jats:italic>P\u00a0<\/jats:italic>= 0.037), and maximum clot firmness was significantly decreased (<jats:italic>P\u00a0<\/jats:italic>= 0.038) in the HES group compared to the CRYS group at T<jats:sub>1<\/jats:sub>. The percentage change in EXTEM clotting time (<jats:italic>P\u00a0<\/jats:italic>= 0.012) and INTEM clot formation time (<jats:italic>P\u00a0<\/jats:italic>= 0.031) was greater after HES than CRYS. Lysis indices remained at 100% for all ROTEM assays in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to a 3\u2010fold volume of CRYS, administration of HES was associated with impairment in ROTEM parameters in dogs with SHP, but no evidence of hyperfibrinolysis was detected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13018","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T17:18:12Z","timestamp":1603819092000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A prospective randomized open\u2010label trial on the comparative effects of 6% hydroxyethyl starch 130\/0.4 versus polyionic isotonic crystalloids on coagulation parameters in dogs with spontaneous hemoperitoneum"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-7627","authenticated-orcid":false,"given":"Claudia","family":"Iannucci","sequence":"first","affiliation":[{"name":"Division of Small Animal Emergency and Critical Care Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dirkmann","sequence":"additional","affiliation":[{"name":"Clinic for Anesthesiology and Intensive Care Essen University Hospital  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Howard","sequence":"additional","affiliation":[{"name":"Clinical Diagnostic Laboratory Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja N.","family":"Adamik","sequence":"additional","affiliation":[{"name":"Division of Small Animal Emergency and Critical Care Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.10.1385"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.247.6.636"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12090"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(00)50044-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/0450072"},{"key":"e_1_2_8_7_1","first-page":"250","article-title":"Splenic masses in dogs. Part 1: epidemiologic, clinical characteristics as well as histopathologic diagnosis in 249 cases (2000\u20102011)","volume":"40","author":"Eberle N","year":"2012","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/0390518"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.4.553"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb00923.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.08.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12346"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12130"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.03.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2006.00184.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2017.00140"},{"key":"e_1_2_8_17_1","first-page":"309","article-title":"Limited fluid volume resuscitation","volume":"31","author":"Hammond TN","year":"2009","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.00138.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.05.015"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6085"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f2e9b2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12281"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00031"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12208"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12283"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204242"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00816.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12320"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12556"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12468"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2018.00279"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00302.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318220755c"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182aa9c9f"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0552.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.3.251"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32833e9c47"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.6.789"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12144"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15365"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.08.022"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2008.11.002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000219"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14853"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1985.25385219903.x"},{"key":"e_1_2_8_46_1","first-page":"556","article-title":"Effect of hydroxyethyl starch on the structure of thrombin\u2010 and reptilase\u2010induced fibrin gels","volume":"108","author":"Carr ME","year":"1986","journal-title":"J Lab Clin Med"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00003.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12492"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12127"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2011.00707.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.12.1908"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2002.32647"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000280481.18570.27"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.03.008"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.652"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.13018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:28:49Z","timestamp":1693711729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/vec.13018"],"URL":"https:\/\/doi.org\/10.1111\/vec.13018","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2018-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}