{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:06:15Z","timestamp":1788282375686,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the use of therapeutic membrane\u2010based plasma exchange (TPE) for treatment of clinical signs associated with suspected acquired myasthenia gravis (MG) in 3 dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case series summary<\/jats:title><jats:p>Three dogs presented with clinical signs consistent with acquired MG. All 3 dogs were medically managed prior to being treated with TPE. Two of the 3 dogs had increased acetylcholine receptor antibody titers that decreased after TPE. One dog diagnosed with primary MG became clinically normal after 2 sessions of TPE and continued to do well with medical management several months later. The second dog was diagnosed with a suspect thymoma, and TPE was performed as a bridge to surgery, with marked improvement of clinical signs after TPE. The dog was ultimately diagnosed with a thymic carcinoma. The third dog had a positive acetylcholine antibody titer and was ultimately diagnosed with hemangiosarcoma (spleen and liver) and invasive mediastinal thymoma. This dog developed severe pneumonia, was ventilator dependent, and died of multiple organ dysfunction. No immediate complications were observed secondary to TPE. All 3 dogs were concurrently treated with either immunosuppressive agents, anticholinesterase drugs, or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or unique information provided<\/jats:title><jats:p>The use of TPE in dogs with MG appears to be well tolerated and safe. It may be a reasonable adjunct therapy to acetylcholinesterase drugs in cases that are not responding to medical management alone. Therapeutic plasma exchange might also be considered preoperatively to prevent postoperative complications in dogs with severe MG, although further studies should be performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13022","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T23:29:57Z","timestamp":1605914997000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic plasma exchange as adjunct therapy in 3 dogs with myasthenia gravis and myasthenia\u2010like syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Amber","family":"Vitalo","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Florida College of Veterinary Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-4764","authenticated-orcid":false,"given":"Gareth","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Florida College of Veterinary Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-926X","authenticated-orcid":false,"given":"Leonel","family":"Londo\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Florida College of Veterinary Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2011.00636.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00244.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285608093888"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-829595"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21470_c"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.148631"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12629"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12608"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12607"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12729"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12549"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12622"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.9.1108"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13596"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00073.x"},{"issue":"6","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2460\/javma.1998.212.06.830","article-title":"Acute fulminating myasthenia gravis in 5 dogs","volume":"212","author":"King LG","year":"1998","journal-title":"J Am Vet Med Assoc"},{"issue":"8","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.2460\/javma.1990.196.08.1276","article-title":"Clinical remission following plasmapheresis and corticosteroid treatment in a dog with acquired myasthenia gravis","volume":"196","author":"Bartges JW","year":"1990","journal-title":"J Am Vet Med Assoc"},{"issue":"8","key":"e_1_2_9_20_1","first-page":"EC35","article-title":"Therapeutic plasma exchange\u2014an emerging treatment modality in patients with neurologic and non\u2010neurologic diseases","volume":"11","author":"Bobati Shreedevi S","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193723"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13300"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6194-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-017-0806-7"},{"issue":"5","key":"e_1_2_9_25_1","first-page":"557","article-title":"Severe pemphigus vulgaris: successful combination therapy of plasmapheresis followed by intravenous high\u2010dose immunoglobulin to prevent rebound increase in pathogenic IgG","volume":"18","author":"Aoyama Y","year":"2008","journal-title":"Eur J Derm"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.11.1596"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.13022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T20:39:38Z","timestamp":1723927178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/vec.13022"],"URL":"https:\/\/doi.org\/10.1111\/vec.13022","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]},"assertion":[{"value":"2018-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}