{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:39:19Z","timestamp":1774690759768,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the use of therapeutic plasma exchange (TPE) in the treatment of flunixin meglumine overdose in a cria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 3\u2010day\u2010old alpaca cria was diagnosed with ureteral obstruction and agenesis resulting in severe bilateral hydronephrosis. During hospitalization, the cria inadvertently received a flunixin meglumine overdose of\u00a0&gt;65\u00a0mg\/kg. Here, we report the use of lipid emulsion and TPE to mitigate flunixin meglumine toxicosis. TPE appeared to prevent any flunixin\u2010induced kidney or gastrointestinal injury, even in a patient with congenital defects of the urinary tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>New Information Provided<\/jats:title><jats:p>This is the first report of the use of TPE in a cria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13071","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T02:32:18Z","timestamp":1620354738000},"page":"521-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic plasma exchange to mitigate flunixin meglumine overdose in a cria"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-3276","authenticated-orcid":false,"given":"Claire E.","family":"Dixon","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings Veterinary Medical Center North Grafton Massachusetts USA"},{"name":"Present address: Claire E. Dixon, School of Veterinary Medicine University of Glasgow Glasgow G12 8QQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Kelley","sequence":"additional","affiliation":[{"name":"Friendship Hospital for Animals Washington D.C. USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Michael","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings Veterinary Medical Center North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisha","family":"Gruntman","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings Veterinary Medical Center North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha","family":"Oura","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Hospital San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa R.","family":"Mazan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings Veterinary Medical Center North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anna","family":"Labato","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings Veterinary Medical Center North Grafton Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2460\/javma.1993.202.01.71","article-title":"Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses","volume":"202","author":"MacAllister CG","year":"1993","journal-title":"J Am Vet Med Assoc"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"195","article-title":"Clinical and pathological effects of flunixin meglumine administration to neonatal foals","volume":"53","author":"Carrick JB","year":"1989","journal-title":"Can J Vet 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