{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:40:56Z","timestamp":1771620056237,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To document the admission systolic blood pressure (SBP), heart rate (HR), and modified Glasgow coma scale (MGCS) score in dogs with and without brain herniation and to determine their relationship with brain herniation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study between 2010 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University veterinary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010four client\u2010owned dogs with brain herniation and 40 client\u2010owned dogs as a control group, as determined on magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>SBP, HR, MGCS score, and outcome were extracted from medical records. MGCS score was retrospectively calculated based on initial neurological examination in dogs with adequate available information. Dogs with brain herniation had a significantly higher SBP (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0078), greater SBP\u2013HR difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006), and lower MGCS score (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) compared to control dogs. A cutoff value of an SBP\u00a0\u2265\u00a0178 mm Hg, SBP\u2013HR\u00a0\u2265\u00a060, and MGCS score\u00a0\u2264\u00a014 each provides a specificity of 90%\u201398%. A combination of an SBP\u00a0&gt;\u00a0140 mm Hg and HR\u00a0&lt;\u00a080\/min provided 24% sensitivity and 100% specificity to diagnose dogs with brain herniation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high SBP, a greater difference between SBP and HR, a combination of higher SBP and lower HR, and a low MGCS score were associated with brain herniation in dogs presenting with neurological signs upon admission. Early recognition of these abnormalities may help veterinarians to suspect brain herniation and determine timely treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13147","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T12:20:29Z","timestamp":1633609229000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retrospective evaluation of the relationship between admission variables and brain herniation in dogs (2010\u20132019): 54 cases"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-591X","authenticated-orcid":false,"given":"Jiwoong","family":"Her","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine  Auburn Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy B.","family":"Yanke","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine  Auburn Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-685X","authenticated-orcid":false,"given":"Katherine","family":"Gerken","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Auburn University College of Veterinary Medicine  Auburn Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Veterinary Surgical Centers  Vienna Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley Antonia","family":"Peters","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Group  Commack New York 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