{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:10Z","timestamp":1747188370067,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the impact of an IV bolus of hydroxyethyl starch 130\/0.4 (HES) or hypertonic saline 7.5% (HS) on hemostasis in dogs resuscitated for gastric\u2010dilation\u2010volvulus (GDV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Open\u2010label, parallel\u2010group randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010three client\u2010owned dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Dogs affected by GDV and shock were randomly assigned to receive HES at 10\u00a0mL\/kg or HS at 4\u00a0mL\/kg every 15 minutes. Blood samples were collected for blood gas analysis, PCV, total plasma protein, albumin, standard coagulation profile, and thromboelastometry (ROTEM) at baseline (T0) and at the end of bolus (T1). To assess the differences between the 2 groups at T1, Student's <jats:italic>t<\/jats:italic>\u2010test or Wilcoxon rank\u2010sum test was used. To evaluate the differences between T0 and T1, ANOVA for paired data or Wilcoxon matched\u2010pairs signed\u2010ranks test was used. <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement and main results<\/jats:title><jats:p>Hemostasis was evaluated by means of prothrombin time, activated partial thromboplastin time, fibrinogen, and ROTEM. The study included 13 dogs in the HES group and 10 dogs in the HS group. Differences were found between groups at T1: increase in clotting time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) and decrease in fibrinogen level (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021) in the HS\u2010treated group.<\/jats:p><jats:p>Between T0 and T1, there were differences for the HES group: increase in clot formation time (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.046), decrease in maximum clot firmness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) in ex\u2010TEM profile, and decrease in maximum clot firmness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0117) in fib\u2010TEM profile. Between T0 and T1, the following differences were noted for the HS group: increase in clotting time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048) and clot formation time (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0019), decrease in maximum clot firmness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031) and \u03b1 angle (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.036) in ex\u2010TEM profile, decrease in \u03b1 angle (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.036) in in\u2010TEM profile, and decrease in maximum clot firmness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) in fib\u2010TEM profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In dogs affected by GDV, HES or HS infusion caused a similar tendency toward hypocoagulability, with few differences between the 2 groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13148","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T04:58:56Z","timestamp":1634792336000},"page":"698-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of hemostasis in dogs with gastric\u2010dilation\u2010volvulus, during resuscitation with hydroxyethyl starch (130\/0.4) or hypertonic saline (7.5%)"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-4680","authenticated-orcid":false,"given":"Antonio","family":"Borrelli","sequence":"first","affiliation":[{"name":"Department of Veterinary Science University of Turin  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Giunti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Science University of Bologna  Bologna 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