{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:50:42Z","timestamp":1774529442856,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the indications and clinical response for dogs and cats treated with esmolol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective case series from 2003 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single university veterinary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010two dogs and 6 cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Animals received either a bolus or bolus and continuous rate infusion of the ultrashort\u2010acting beta receptor antagonist, esmolol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Twenty\u2010two animals were treated for either a supraventricular or sinus tachycardia, 5 were treated for a ventricular tachycardia, and 1 was treated for atrial fibrillation. Esmolol was most frequently used in dogs (<jats:italic>N<\/jats:italic> = 9) who had ingested a toxin such as albuterol, amphetamine, or chocolate. Esmolol was administered at median bolus dose of 330 \u00b5g\/kg (range 10\u20131000 \u00b5g\/kg) and continued as a continuous rate infusion in 15 animals at a median dose of 50 \u00b5g\/kg\/min. Defining success as a reduction in heart rate of 20% or greater, esmolol therapy was considered successful in 13 of 28 animals (46%).\u00a0Animals treated for a toxicosis were more likely to have a successful rate reduction than those treated for other causes (<jats:italic>P<\/jats:italic> = 0.006). Nineteen animals survived to discharge. Both treatment success (<jats:italic>P<\/jats:italic> = 0.046) and treatment for a toxicosis (<jats:italic>P<\/jats:italic> = 0.003) were associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Esmolol administration was well tolerated by dogs and cats with tachycardia due to intoxication. Heart rate reduction by at least 20% was achieved in 46% of cases. Animals with toxin ingestion were more likely to be discharged from the hospital.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13162","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T14:20:23Z","timestamp":1638886823000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of esmolol for control of tachycardia in 28 dogs and cats (2003\u20132020)"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-6124","authenticated-orcid":false,"given":"Michael","family":"Verschoor\u2010Kirss","sequence":"first","affiliation":[{"name":"VCA South Shore Animal Hospital  535 Columbian St. South Weymouth MA 02190"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-8930","authenticated-orcid":false,"given":"Elizabeth","family":"Rozanski","sequence":"additional","affiliation":[{"name":"Department 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