{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:01:50Z","timestamp":1773687710970,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe renal tubular acidosis (RTA) and secondary acquired hyperaldosteronism in a cat as an adverse effect of topiramate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>An 8\u2010year\u2010old neutered female cat on chronic oral topiramate therapy at a recommended dose (11.9\u00a0mg\/kg q 8\u00a0h) for seizure control was presented with severe metabolic acidosis and hypokalemia. Plasma electrolyte and acid\u2013base analysis identified a severe metabolic acidosis (pH 7.153, reference interval: 7.31\u20137.46), hypokalemia (2.08\u00a0mmol\/L [2.08\u00a0mEq\/L], reference interval: 3.5\u20134.8\u00a0mmol\/L [3.5\u20134.8\u00a0mEq\/L]), and ionized hypercalcemia (1.85\u00a0mmol\/L [1.85\u00a0mEq\/L], reference range: 1.1\u20131.4\u00a0mmol\/L [1.1\u20131.4\u00a0mEq\/L]). Urinalysis revealed a urine specific gravity of 1.021 and a pH of 7.0. Diagnostic workup suggested distal RTA as a cause of the cat's acid\u2013base and electrolyte disturbances. Aldosterone concentration was moderately increased, suggestive of secondary hyperaldosteronism. The metabolic abnormalities resolved with supportive care and discontinuation of topiramate.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>Topiramate is suggested to have led to the development severe RTA in a cat.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13168","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T11:19:24Z","timestamp":1644491964000},"page":"420-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Presumptive renal tubular acidosis secondary to topiramate administration in a cat"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-5760","authenticated-orcid":false,"given":"Steven J.","family":"Centola","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kaiman","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaila","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yekaterina","family":"Buriko","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Matthew J. 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