{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:13:51Z","timestamp":1790864031195,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical presentation and management of a critically ill dog with profound renal tubular acidosis (RTA) with proximal and distal renal tubular dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 3\u2010year\u2010old neutered female Border Terrier was presented with frequent regurgitation resulting from acute pancreatitis with severe ileus. Venous acid\u2013base analysis and complete urinalysis confirmed the presence of normal anion gap metabolic acidosis with inappropriately alkaline urine (pH 8), consistent with distal RTA. Urinalysis, urine amino acids, and urinary fractional excretion of electrolytes revealed glycosuria (with normoglycemia), aminoaciduria, and increased fractional excretion of sodium, calcium, and phosphate consistent with generalized proximal renal tubulopathy or Fanconi syndrome. The dog responded well to supportive care and alkaline therapy and made a complete recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>To the authors\u2019 knowledge, this is the first description of RTA with proximal and distal renal tubular dysfunction in the veterinary literature. Furthermore, the authors hypothesize that the transient RTA was a manifestation of acute kidney injury secondary to acute pancreatitis, the first report of this in the literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13186","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T13:35:00Z","timestamp":1644240900000},"page":"524-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute kidney injury manifesting as renal tubular acidosis with proximal and distal renal tubular dysfunction in a dog with acute pancreatitis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-2085","authenticated-orcid":false,"given":"James C.","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u2010John","family":"M\u00e4ntyl\u00e4 Noble","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"issue":"7","key":"e_1_2_7_2_1","first-page":"513","article-title":"Renal tubular acidosis","volume":"27","author":"Riordan L","year":"2005","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02311.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000023430.92674.E5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050354"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2001.tb06025.x"},{"key":"e_1_2_7_7_1","first-page":"635","article-title":"Fanconi syndrome and acute renal failure associated with gentamicin therapy in a dog","volume":"22","author":"Brown SA","year":"1986","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.15654\/TPK-140841"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12100"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03249.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12065"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0406.x"},{"issue":"2","key":"e_1_2_7_13_1","first-page":"174","article-title":"Transient distal renal tubular acidosis in a dog with gastric\u2010dilatation\u2010volvulus","volume":"60","author":"Torrente C","year":"2019","journal-title":"Can Vet J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5993"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00801.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2013.048"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.01.002"},{"issue":"5","key":"e_1_2_7_18_1","first-page":"713","article-title":"Serum proteins and acid\u2010base equilibria: a follow\u2010up","volume":"120","author":"Figge J","year":"1992","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12215"},{"key":"e_1_2_7_20_1","volume-title":"Clinical Physiology of Acid\u2010Base and Electrolyte Disorders","author":"Rose BD","year":"2001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2019.07.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000185243"},{"issue":"10","key":"e_1_2_7_23_1","first-page":"938","article-title":"Glucosuria associated with renal tubular dysfunction in 3 Basenji dogs","volume":"168","author":"Easley JR","year":"1976","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03256.x"},{"issue":"8","key":"e_1_2_7_25_1","first-page":"1201","article-title":"Temporary remission of hypoglycemia in a dog with an insulinoma after treatment with streptozotocin","volume":"38","author":"Meyer DJ","year":"1977","journal-title":"Am J Vet Res"},{"issue":"7","key":"e_1_2_7_26_1","first-page":"765","article-title":"Effects of tetracycline on the dog kidney. 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