{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:01:35Z","timestamp":1773687695333,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the successful treatment of a life\u2010threatening type III hypersensitivity reaction suspected to have been related to human serum albumin (HSA) administration in a dog with therapeutic plasma exchange (TPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 3\u2010year\u2010old neutered male mixed breed dog was suspected to have developed immune\u2010mediated vasculitis 2\u00a0weeks after the administration of HSA (740\u00a0mg\/kg) for the management of hypoalbuminemia resulting from septic peritonitis. The dog was presented with fever, edema, hypoalbuminemia (26\u00a0g\/L [2.6\u00a0g\/dL]; reference interval, 30\u201344\u00a0g\/L [3.0\u20104.4\u00a0g\/dL]), and coagulopathy. The dog was treated with fresh frozen plasma (FFP) and glucocorticoids but remained hypoalbuminemic (18\u00a0g\/L [1.8\u00a0g\/dL]) and developed acute kidney injury (AKI). Over 4 days, 3 TPE treatments were performed, with a total of 2.7 plasma volumes exchanged. Replacement fluids consisted of a combination of FFP, hydroxyethyl starch 6%, and 0.9% saline solution. Following TPE treatments, serum albumin concentration increased (from 18\u00a0g\/L [1.8\u00a0g\/dL] to 25\u00a0g\/L [2.5\u00a0g\/dL]), serum creatinine concentration decreased (from 340\u00a0\u03bcmol\/L [3.9\u00a0mg\/dL] to 87\u00a0\u03bcmol\/L [0.98\u00a0mg\/dL]), and clotting times normalized (activated partial thromboplastin time decreased from 33 seconds to 14.5 seconds). There was a gradual but consistent clinical improvement of the edema and overall demeanor of the dog. No significant adverse effects were noted during the TPE treatments, and the dog was discharged after 8 days of hospitalization. Following discharge, the dog had complete clinical resolution of edema and AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>New\/unique\u00a0information<\/jats:title><jats:p>This is the first report describing successful use of TPE for the management of an immune\u2010mediated reaction (type III hypersensitivity) following HSA administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13188","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:39:20Z","timestamp":1646221160000},"page":"532-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic plasma exchange for the management of a type III hypersensitivity reaction and suspected immune\u2010mediated vasculitis assumed to be caused by human albumin administration in a dog"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-4496","authenticated-orcid":false,"given":"Sigal","family":"Klainbart","sequence":"first","affiliation":[{"name":"Department of\u00a0Small Animal Emergency and Critical Care, The Veterinary Teaching Hospital, Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-3159","authenticated-orcid":false,"given":"Gilad","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine, The Veterinary Teaching Hospital, Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2809-0442","authenticated-orcid":false,"given":"Efrat","family":"Kelmer","sequence":"additional","affiliation":[{"name":"Department of\u00a0Small Animal Emergency and Critical Care, The Veterinary Teaching Hospital, Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-9484","authenticated-orcid":false,"given":"Hilla","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine, The Veterinary Teaching Hospital, Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1435-6935.2002.00025.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.1995.tb00026.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.00141.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.4.607"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.6.657"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12484"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.7.1004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21257"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12629"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15528"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0654-3.00008-1"},{"key":"e_1_2_7_13_1","first-page":"932","article-title":"Albumin in health and disease: protein metabolism and function","volume":"26","author":"Throop JL","year":"2004","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_7_14_1","first-page":"HS15","article-title":"Clinical review of appropriate uses for albumin","volume":"23","author":"Gonzalez ER","year":"1998","journal-title":"US Pharm"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00819.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.4.486"},{"issue":"12","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.2460\/javma.1992.200.12.1859","article-title":"Clinical aspects of septic shock and comprehensive approaches to treatment in dogs","volume":"200","author":"Weeren FR","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-039236-0.50012-6"},{"key":"e_1_2_7_19_1","first-page":"561","volume-title":"Kirk and Bistner's Handbook of Veterinary Procedures and Emergency Treatment","author":"Kristensen AT","year":"1995"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12280"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7153.235"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040232"},{"key":"e_1_2_7_23_1","first-page":"164","volume-title":"All About Albumin: Biochemistry, Genetics, and Medical Applications","author":"Peters T","year":"1996"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.6.873"},{"issue":"6","key":"e_1_2_7_25_1","first-page":"591","article-title":"A retrospective analysis of 25% human serum albumin supplementation in hypoalbuminemic dogs with septic peritonitis","volume":"56","author":"Horowitz FB","year":"2015","journal-title":"Can Vet J"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2010.00526.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12085"},{"key":"e_1_2_7_28_1","first-page":"332","volume-title":"Veterinary Immunology","author":"Tizard IR","year":"2000"},{"key":"e_1_2_7_29_1","first-page":"10","volume-title":"Essentials of Clinical Immunology","author":"Chapel H","year":"2014"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2006.07.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2049-8"},{"key":"e_1_2_7_32_1","first-page":"904","volume-title":"Schalm's Veterinary Hematology","author":"Modiano J","year":"2000"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21561"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21098"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000165093.13046.B3"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91079-0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02621.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90151-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000188945.20977.94"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00431.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2018.00161"},{"issue":"8","key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.2460\/javma.1990.196.08.1276","article-title":"Clinical remission following plasmapheresis and corticosteroid treatment in a dog with acquired myasthenia gravis","volume":"196","author":"Bartges JW","year":"1990","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.9.1108"},{"issue":"6","key":"e_1_2_7_44_1","first-page":"595","article-title":"Plasmapheresis in five dogs with systemic immune\u2010mediated disease","volume":"187","author":"Matus RE","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12976"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.13188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T17:04:45Z","timestamp":1726765485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/vec.13188"],"URL":"https:\/\/doi.org\/10.1111\/vec.13188","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]},"assertion":[{"value":"2020-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}