{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:49:23Z","timestamp":1770227363037,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate agreement between 2 standard laboratory (SL) methods and an immunochromatographic strip (ICS) method to crossmatch dogs receiving RBC transfusions.\u00a0A second objective was to evaluate uninterpretable SL crossmatch results as compared to ICS in the presence of autoagglutination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study (September 2018 to October 2019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty anemic dogs receiving RBC transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement and Main Results<\/jats:title><jats:p>All dogs received DEA 1\u2010negative packed RBCs. Three crossmatch methods were evaluated against the same unit transfused to each dog: SL method performed at institutional laboratory (SL\u2010I), SL method sent to a commercial laboratory (SL\u2010C), and a commercially available point\u2010of\u2010care ICS method. Major and minor crossmatches were incompatible for 2.5%\/7.5% of ICS tests, 82.5%\/52.5% of SL\u2010I tests, and 52.5%\/27.5% of SL\u2010C tests.\u00a0Agreement between ICS and SL\u2010C major (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a00.05) and minor (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a00.02) crossmatches and between ICS and SL\u2010I major (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a00.009) and minor (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a00.03) crossmatches was slight. Agreement between SL\u2010C and SL\u2010I major (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a0\u20130.06) and minor (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a0\u20130.12) crossmatches was poor. Results of major and minor crossmatches were uninterpretable due to autoagglutination in 38%\/38% for SL\u2010I and 29%\/18% for SL\u2010C crossmatches. ICS method was interpretable for 93% (major) and 98% (minor) crossmatches. After exclusion of uninterpretable SL pairings, agreement still remained poor to slight between all tests. Only 1 of 40 dogs (2.5%; 95% confidence interval:\u00a0&lt;1.0%\u201313.2%) had an immediate immunological transfusion reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lack of agreement between all methodologies was noted. The high level of incompatibility predicted by SL methods despite lack of clinically relevant reactions suggests a high false incompatibility rate as compared to the ICS test. ICS testing was also able to give results more frequently in the face of autoagglutination.\u00a0Further work is needed to investigate the ICS method's ability to predict clinically significant transfusion reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13219","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T13:44:31Z","timestamp":1657892671000},"page":"582-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of a commercial immunochromatographic strip crossmatch kit and standard laboratory crossmatch methods for blood transfusion compatibility in dogs"],"prefix":"10.1111","volume":"32","author":[{"given":"Rebecca M.","family":"Zaremba","sequence":"first","affiliation":[{"name":"Emergency and Critical Care Department IndyVet Emergency &amp; Specialty Hospital  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee C.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Thomovsky","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Veterinary Administration Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.02.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-2591-7.10066-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.03.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2018.12.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14572"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12433"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29289146847.x"},{"key":"e_1_2_9_9_1","first-page":"333","volume-title":"Textbook of Small Animal Critical Care Medicine","author":"McMichael M","year":"2009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.250.3.303"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638716668626"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000619"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00387.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14801"},{"issue":"3","key":"e_1_2_9_15_1","first-page":"751","article-title":"Prevalence and mode of inheritance of the dal blood group in dogs in North America","volume":"31","author":"Goulet S","year":"2017","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638718806023"},{"issue":"10","key":"e_1_2_9_17_1","first-page":"447","article-title":"An update on blood typing, crossmatching, and doing no harm in transfusing dogs and cats","volume":"105","author":"Vap LM","year":"2010","journal-title":"Vet Med"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0654-3.00031-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(03)00093-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb02961.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15983"},{"key":"e_1_2_9_22_1","unstructured":"Alvedia: Alice Veterinary Diagnostic. 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