{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:05:31Z","timestamp":1785863131948,"version":"3.56.0"},"reference-count":82,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of point\u2010of\u2010care biochemical variables obtained during CPR or within 24\u00a0hours of return of spontaneous circulation (ROSC) with patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Ninety\u2010four dogs and 27 cats undergoing CPR according to the Reassessment Campaign on Veterinary Resuscitation guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Blood gas, acid\u2013base, electrolyte, glucose, and plasma lactate values obtained during CPR or within 24\u00a0hours of ROSC were retrospectively evaluated and are described. The blood sample type and collection time with respect to CPR initiation and ROSC were recorded. Measured variables, collection times, and species were included in a multivariable logistic regression model to estimate the odds ratio (OR) and 95% confidence interval of ROSC, sustained ROSC (\u226520\u00a0min), and survival to hospital discharge. Significance was set at <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05. Seventy\u2010two venous blood samples obtained during CPR and 45 first venous and arterial blood samples obtained after ROSC were included in logistic regression analysis. During CPR, PvO<jats:sub>2<\/jats:sub> (1.09 [1.036\u20131.148], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and venous standard base excess (SBE) (1.207 [1.094\u20131.331], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were associated with ROSC. PvO<jats:sub>2<\/jats:sub> (1.075 [1.028\u20131.124], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), SBE (1.171 [1.013\u20131.353], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032), and potassium concentration (0.635 [0.426\u20130.946], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026) were associated with sustained ROSC. Potassium concentration (0.235 [0.083\u20130.667], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) was associated with survival to hospital discharge. Following ROSC, pH (69.110 [4.393\u20131087], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), potassium concentration (0.222 [0.071\u20130.700], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010), and chloride concentration (0.805 [0.694\u20130.933], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) were associated with survival to hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biochemical variables such as PvO<jats:sub>2<\/jats:sub>, SBE, and potassium concentration during CPR and pH, potassium, and chloride concentration in the postarrest period may help identify dogs and cats with lower odds for ROSC or survival to hospital discharge following 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