{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:27Z","timestamp":1747188387035,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the therapeutic protocol used to normalize severe hypertriglyceridemia in a dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>A 7\u2010month\u2010old, 1.2\u2010kg female Pomeranian presented with acute polyuria, polydipsia, and ocular discoloration. Diagnoses included diabetic ketosis, severe hypertriglyceridemia (&gt;225\u00a0mmol\/L [&gt;20,000\u00a0mg\/dl]), lipemia retinalis, and bilateral uveitis. The triglyceride concentration was near normal within 2\u00a0days of initiating treatment with fenofibrate, regular insulin constant rate infusion (CRI), manual therapeutic plasma exchange (TPE), and a low\u2010fat diet. All clinical signs resolved. The dog has had no relapse of hypertriglyceridemia at the time of writing the manuscript, 6\u00a0months later, with continued treatment of diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This is the first case report documenting the combination of fenofibrate, insulin CRI, and manual TPE for treatment of severe hyperlipidemia in a dog. Detailed protocols for manual TPE and a novel insulin CRI are provided. A discussion of multiple spurious biochemical and hematologic errors associated with the severe hypertriglyceridemia is also provided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13275","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T08:55:18Z","timestamp":1672131318000},"page":"247-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-3245","authenticated-orcid":false,"given":"Aria L.","family":"Guarino","sequence":"first","affiliation":[{"name":"Blue Pearl Veterinary Partners  Rockville Maryland USA"},{"name":"Small Animal Hospital, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Cagle","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratories, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0112-3163","authenticated-orcid":false,"given":"Caryn M.","family":"Ehrhardt","sequence":"additional","affiliation":[{"name":"Small Animal Hospital, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah S. 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