{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:10:12Z","timestamp":1783962612607,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the use of a modified Sepsis\u20103 (mSepsis\u20103) definition compared to the currently used modified Sepsis\u20102 (mSepsis\u20102) definition to determine whether the mSepsis\u20102 or mSepsis\u20103 stratifications were able to identify populations of dogs ultimately more likely to die from canine parvovirus (CPV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective, January 2009 to March 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A private, small animal, urban, referral emergency and specialty hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010nine client\u2010owned dogs hospitalized for treatment of CPV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Dogs were divided into mSepsis\u20102 and mSepsis\u20103 categories based on the highest level of illness severity reached during hospitalization. Greater illness severity based on mSepsis\u20102 criteria (ie, sepsis, severe sepsis, septic shock) was associated with an increase in average length of stay (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), increase in average cost of stay (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and presence of leukopenia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). An increase in illness severity within the mSepsis\u20102 criteria was not associated with hyperlactatemia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.29), presence of neutropenia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.12), or mortality (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.35). Greater illness severity based on mSepsis\u20103 criteria (ie, infection only, sepsis, septic shock) was associated with an increase in mortality (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), increase in average length of stay (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), increase in average cost of stay (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), presence of leukopenia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and presence of neutropenia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The mSepsis\u20103 criteria were not associated with the presence of hyperlactatemia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.68). There was no significant difference between survivors and nonsurvivors in the presence of leukopenia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.19), neutropenia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.67), or hyperlactatemia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mSepsis\u20103 diagnostic criteria appear to better identify dogs with CPV at higher risk for mortality compared to the mSepsis\u20102 criteria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13276","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T13:35:05Z","timestamp":1677159305000},"page":"208-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A comparison of the Sepsis\u20102 and Sepsis\u20103 definitions for assessment of mortality risk in dogs with 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