{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:22:14Z","timestamp":1769559734894,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe patient characteristics, underlying disease processes, clinical outcomes, transfusion dose and type (therapeutic or prophylactic), platelet count changes, and adverse events associated with platelet concentrate (PC) administration in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>A total of 149 dogs, representing 189 PC transfusion episodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>In this population, 39 of 149 dogs (26.2%) were diagnosed with primary immune\u2010mediated thrombocytopenia, 22 of 149 (14.8%) had decreased bone marrow production, 12 of 149 (8.0%) received PC during a massive transfusion, 3 of 149 (2.0%) had congenital thrombocytopathia, 59 of 149 (39.6%) had severe thrombocytopenia of other causes, and 14 of 149 (9.4%) underwent transfusion for miscellaneous causes without a documented severe thrombocytopenia. In 117 of 149 dogs (78.5%), &gt;1 site of hemorrhage was noted. The most common sites of hemorrhage were the gastrointestinal (GI) tract in 89 of 149 (59.7%) and the skin in 78 of 149 (52.3%). Overall survival to discharge was 59.1% (88\/149). The median PC dose was 0.8 units per 10\u00a0kg of body weight per transfusion episode (range: 0.2\u20136.7). Of 189 episodes, 29 of 189 (15.7%) were prophylactic, and 158 of 189 (83.6%) were therapeutic. For 99 of 189 transfusion episodes, paired pre\u2010 and postplatelet counts were available within 24\u00a0hours. The median platelet count change was 5.0\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (5000\/\u03bcL; range: \u2013115\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L to 158\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L [\u2013115,000 to 158,000\/\u03bcL]); the posttransfusion platelet count was significantly higher than pretransfusion (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The increase in platelet count after transfusion was greater in the prophylactic group than the therapeutic group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0167). Transfusion reactions were suspected during 2 of 168 episodes (1.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immune\u2010mediated thrombocytopenia was the most common disease process that resulted in PC transfusion. PC was more frequently administered to animals with active hemorrhage rather than prophylactically, and most dogs had evidence of hemorrhage in multiple organ systems, particularly the GI tract and skin. PC transfusions typically appeared safe, and the median platelet count increased after transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13281","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T15:29:21Z","timestamp":1676647761000},"page":"360-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retrospective evaluation of fresh platelet concentrate administration in dogs: Patient characteristics, outcomes, and transfusion practices in 189 transfusion episodes (2008\u20132019)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-9156","authenticated-orcid":false,"given":"Laurence M.","family":"Saint\u2010Pierre","sequence":"first","affiliation":[{"name":"William R. 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