{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T22:52:12Z","timestamp":1752101532395,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical signs and outcomes observed after<jats:italic>Humulus lupulus<\/jats:italic>(hops) ingestion in dogs. A secondary objective was to note any trends in the number of hops\u2010related phone calls made to an animal poison control center over a 13\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study (2005\u20132018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An animal poison control center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>One hundred and seventy\u2010seven dogs with known or suspected hops ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>A total of 177 calls were made to Pet Poison Helpline between 2005 and 2018 involving hops ingestion in dogs. Outcomes were determined in 83 cases; 79 of 83 (95.2%) survived. Clinical signs associated with hops ingestion were observed in 74.0% (131\/177). Commonly observed clinical signs were tachypnea (98\/131), hyperthermia (65\/131), and vomiting (44\/131). Severe hyperthermia (&gt;41.4\u00b0C, [&gt;106\u00b0F]) developed in 8 dogs and 3 of those dogs did not survive. A fourth nonsurvivor was found deceased at home. The majority of symptomatic dogs developed clinical signs between 2 and 8\u00a0hours postingestion. Resolution of clinical signs occurred in less than 24\u00a0hours in all survivors except in one. Cases consulted with Pet Poison Helpline related to hops ingestion increased from 2005 to 2018 relative to the total amount of cases managed overall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most common clinical signs associated with hops ingestion include tachypnea, hyperthermia, and vomiting; however, not all dogs develop clinical signs. While prognosis is good with 95.2% of dogs in this population surviving, some dogs can develop a severe and fatal hyperthermia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13282","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:23:34Z","timestamp":1678688614000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A retrospective evaluation of hops ingestion in 177 dogs (2005\u20132018)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-4847","authenticated-orcid":false,"given":"Jami","family":"Becker","sequence":"first","affiliation":[{"name":"Angell Animal Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahna G.","family":"Brutlag","sequence":"additional","affiliation":[{"name":"Pet Poison Helpline and SafetyCall International, LLC Bloomington Minnesota USA"},{"name":"College of Veterinary Medicine University of Minnesota St Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Hovda","sequence":"additional","affiliation":[{"name":"Pet Poison Helpline and SafetyCall International, LLC Bloomington Minnesota USA"},{"name":"College of Veterinary Medicine University of Minnesota St Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-3592","authenticated-orcid":false,"given":"Aaron","family":"Rendahl","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Minnesota St Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"Tart","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Minnesota St Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jib.160"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00345"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.01.011"},{"issue":"1","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2460\/javma.1997.210.01.51","article-title":"Malignant hyperthermia\u2010like reaction secondary to ingestion of hops in five dogs","volume":"210","author":"Duncan KK","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13141"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.05.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-0306-7.00010-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001878"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119421375.ch16"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00026"},{"key":"e_1_2_9_12_1","first-page":"59","article-title":"Exercise\u2010induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels","volume":"8","author":"Thrift E","year":"2017","journal-title":"Vet Med"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/coep.12394"},{"key":"e_1_2_9_14_1","unstructured":"Homebrewing Stats.American Homebrews Association;2017. 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