{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:26:56Z","timestamp":1788820016870,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the point prevalence and duration of hyperfibrinolysis (HF) in dogs undergoing surgical control of spontaneous hemoperitoneum (SHP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single veterinary teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty\u2010five client\u2010owned dogs with SHP were screened for HF. Eighteen HF dogs treated surgically were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Dogs with SHP and evidence of shock admitted for surgical control of hemorrhage were screened for HF. Blood samples were collected for PCV, total plasma protein, platelet count, and thromboelastography with 50\u00a0U\/mL of tissue plasminogen activator at presentation and every 8\u00a0hours postoperatively until 72\u00a0hours, discharge, or death. HF was defined as a tissue plasminogen activator\u2010activated thromboelastography lysis percentage measured 30\u00a0minutes after maximum amplitude (LY30) of \u226520%. LY30 values were compared to a cohort of samples obtained from healthy dogs (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022). The point prevalence of HF in all dogs screened was 40% (18\/45 dogs), and the mean LY30 at baseline for HF dogs was 48.9% (\u00b124.2%), which was significantly higher than that of control dogs (4.8%\u00a0\u00b1\u00a07.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and non\u2010HF dogs (1.9%\u00a0\u00b1\u00a05.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In HF dogs, there was a significant decrease in LY30 between baseline and 8\u00a0hours (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and between 8 and 16\u00a0hours (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.035) but no significant change thereafter. LY30 at 8\u00a0hours (4%, range: 0%\u201323.4%) was not statistically different from control dogs (6.5%, range: 1.2%\u201332.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.664) suggesting early resolution of HF in this population. Only 2 of 18 dogs were persistently hyperfibrinolytic at 24\u00a0hours. Malignancy was diagnosed in 12 of 18 dogs (66.6%), while a benign etiology occurred in 6 of 18 dogs (33.3%). All HF dogs survived to discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HF occurs in some dogs with hypovolemic shock due to hemoperitoneum but resolves rapidly following surgical control of bleeding without antifibrinolytic medications. Routine postoperative use of antifibrinolytics in dogs with hemoperitoneum in dogs undergoing surgical control of bleeding may not be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.13300","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:19:47Z","timestamp":1682209187000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapid resolution of hyperfibrinolysis in dogs with spontaneous hemoperitoneum following surgical control of hemorrhage"],"prefix":"10.1111","volume":"33","author":[{"given":"Ian M.","family":"DeStefano","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Rozanski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Koethe","sequence":"additional","affiliation":[{"name":"Tufts Clinical and Translational Science Institute Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle M.","family":"de Laforcade","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cummings School of Veterinary Medicine Tufts University  North Grafton Massachusetts 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