{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:25:16Z","timestamp":1783790716723,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the major crossmatch compatibility between rabbit recipients, rabbit donors, and the major canine and feline blood types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective in vitro study in December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic veterinary teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Whole blood samples were collected from 11 healthy New Zealand White rabbits (<jats:italic>Oryctolagus cuniculus<\/jats:italic>) with no previous transfusion history. Three pigtail segments were acquired from dog erythrocyte antigen (DEA)\u20101\u2010positive, DEA\u20101\u2010negative, and feline type A blood units. Whole blood was collected from a healthy type B blood donor cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Blood from each rabbit recipient underwent a major crossmatch using standard tube crossmatch methodology with itself and the following donor blood types: rabbit, DEA\u20101\u2010positive, DEA\u20101\u2010negative, feline type A, and feline type B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Self\u2010crossmatches and crossmatches between rabbit recipients and conspecific donors were negative for hemolysis and agglutination. Crossmatches between rabbit recipients and canine and feline donors yielded no hemolysis but produced varying degrees of macroscopic and microscopic agglutination. Rabbit recipients had 1.4 (95% confidence interval: 1.1\u20131.8) times the risk of macroscopic agglutination when major crossmatched with canine blood compared to feline blood. No significant difference in agglutination was found between DEA\u20101\u2010positive and DEA\u20101\u2010negative or feline type A and type B donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings support allogeneic blood transfusions between rabbits being highly compatible and suggest rabbits have naturally occurring alloantibodies against both canine and feline red blood cells. However, feline red blood cells had a lower rate of in vitro incompatibility on major crossmatch, suggesting potentially higher in vivo compatibility if an emergency xenotransfusion is needed. Further prospective research is needed to determine if xenotransfusion is associated with a higher incidence of acute and delayed transfusion reactions in rabbits than allogeneic transfusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13362","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T14:23:48Z","timestamp":1708957428000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Major crossmatch compatibility of rabbit blood with rabbit, canine, and feline blood"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-1881","authenticated-orcid":false,"given":"Nicholas G.","family":"Dannemiller","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-8795","authenticated-orcid":false,"given":"Sarah M.","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A.","family":"Petritz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-0601","authenticated-orcid":false,"given":"Sarah E.","family":"Musulin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.104472"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1638\/2015-0053.1"},{"issue":"0","key":"e_1_2_9_4_1","first-page":"e1","article-title":"Xenotransfusion with packed bovine red blood cells to a wildebeest calf (Connochaetes taurinus)","volume":"89","author":"Buck RK","year":"2018","journal-title":"J S Afr Vet Assoc"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12943"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00387.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"WeinsteinNM SinkCA Blood typing and cross\u2010matching. In:CreedonJMB DavisH eds.Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care.John Wiley & Sons;2012:682\u2010692.","DOI":"10.1002\/9781118997246.ch53"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"GigerU Transfusion therapy. In:SilversteinDC HopperK eds.Small Animal Critical Care Medicine.2nd ed.W.B. Saunders;2015:327\u2010332.","DOI":"10.1016\/B978-1-4557-0306-7.00061-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2018.12.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13149"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13823"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119500537.ch117"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.74.6.432"},{"key":"e_1_2_9_14_1","first-page":"400","article-title":"Longevity of red blood cells in interspecies transfusion","volume":"143","author":"Clark CH","year":"1963","journal-title":"J Am Vet Med Assoc"},{"issue":"12","key":"e_1_2_9_15_1","first-page":"1437","article-title":"Survival of erythrocytes after autologous and allogeneic transfusion in cats","volume":"183","author":"Marion RS","year":"1983","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13096"},{"key":"e_1_2_9_17_1","first-page":"684","article-title":"The effects of repeated transfusions of dog blood to cats","volume":"2","author":"Hessler JD","year":"1962","journal-title":"Small Anim Clin"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12460530"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"2","article-title":"Autologous, homologous, and heterologous red blood cell transfusions in cockatiels (Nymphicus hollandicus)","volume":"13","author":"Degernes LA","year":"1999","journal-title":"J Avian Med Surg"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1647\/1082-6742(2001)015[0010:TOTSMT]2.0.CO;2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13627"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13045"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02493.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1995.206.09.1358"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118933053.ch25"},{"key":"e_1_2_9_26_1","first-page":"268","volume-title":"Modern Blood Banking and Transfusion Practices","author":"Walker PS","year":"2018"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T11:13:22Z","timestamp":1711970002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/vec.13362"],"URL":"https:\/\/doi.org\/10.1111\/vec.13362","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"assertion":[{"value":"2022-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}