{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:08:49Z","timestamp":1782436129378,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019897","name":"South African Veterinary Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe and compare prothrombin time (PT), activated partial thromboplastin time (aPTT), thromboelastography (TEG), HCT, and platelet count measurements in a hemorrhage\/over\u2010resuscitation model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomized crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Anesthetized cats underwent 3 treatments at 2\u2010month intervals. The treatments were as follows: NHR\u2014no controlled hemorrhage and sham resuscitation; LRS\u2014controlled hemorrhage and lactated Ringer's solution (LRS) for resuscitation; and Voluven\u2014controlled hemorrhage and 6% tetrastarch 130\/0.4 for resuscitation. The LRS and Voluven were administered at 60 and 20\u00a0mL\/kg\/h, respectively, for 120\u00a0minutes. Blood samples were drawn for PT, aPTT, TEG, HCT, and platelet count measurements at a healthy check (T \u2212 7d), after controlled hemorrhage (T0), at 60 and 120\u00a0minutes of resuscitation (T60 and T120), and at 24\u00a0hours after completion of resuscitation (T24h). Data were analyzed using a general linear mixed model approach (significance was <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Total median blood loss (controlled hemorrhage and blood sampling from T0 to T120) at T120 was 11.4, 31.0, and 30.8\u00a0mL\/kg for NHR, LRS, and Voluven, respectively. PT and aPTT during LRS and Voluven were prolonged at T60 and T120 compared to NHR (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). On TEG, the reaction time, kinetic time, and alpha\u2010angle were within reference intervals for cats at all time points in all treatments, while maximum amplitude was less than the reference interval (40\u00a0mm) at T0, T60, and T120 during Voluven and at T60 and T120 during LRS compared to NHR (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The HCT and platelet count were significantly lower at T60 and T120 during LRS and Voluven compared to NHR (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypocoagulopathy was observed during hemorrhage and liberal fluid resuscitation. Prolongation of PT and aPPT and decreased clot strength may have been caused by hemodilution and platelet loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13376","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:13:48Z","timestamp":1718363628000},"page":"356-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prothrombin and activated partial thromboplastin times, thromboelastography, hematocrit, and platelet count in a feline hemorrhage\/over\u2010resuscitation model using lactated Ringer's solution or 6% tetrastarch 130\/0.4"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-7726","authenticated-orcid":false,"given":"Gareth E.","family":"Zeiler","sequence":"first","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria  Pretoria South Africa"},{"name":"Anaesthesia and Critical Care Services Valley Farm Animal Hospital  Pretoria South Africa"},{"name":"Brain Function Research Group, School of Physiology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brighton T.","family":"Dzikiti","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria  Pretoria South Africa"},{"name":"Clinical Sciences Department Ross University School of Veterinary Medicine  Basseterre Saint Kitts and Nevis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Rioja","sequence":"additional","affiliation":[{"name":"Optivet Referrals  Havant UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kamerman","sequence":"additional","affiliation":[{"name":"Brain Function Research Group, School of Physiology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne K.","family":"Buck","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Pohlin","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fuller","sequence":"additional","affiliation":[{"name":"Brain Function Research Group, School of Physiology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2019.11.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12354"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12320"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2006.00184.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12283"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0767-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2016.05.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.07.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12144"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12143"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12142"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12147"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12145"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12146"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.04025.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2021.04.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2021.07.004"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016925309136722"},{"key":"e_1_2_11_20_1","first-page":"S1","article-title":"Evaluation of thromboelastography (TEG) in normal cats","volume":"14","author":"Alwood AJ","year":"2004","journal-title":"J Vet Emerg Critic Care"},{"key":"e_1_2_11_21_1","first-page":"1","article-title":"Thromboelastography results on citrated whole blood from clinically healthy cats depends on modes of activation","volume":"52","author":"Marschner CB","year":"2010","journal-title":"Acta Vet Scandin"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12559"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318210385c"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.12.015"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182a92514"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00263.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.6.789"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12584"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5326\/0380499"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2018.06.010"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:59:28Z","timestamp":1723136368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/vec.13376"],"URL":"https:\/\/doi.org\/10.1111\/vec.13376","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"2022-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}