{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:40Z","timestamp":1747188400695,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a case of bifenthrin toxicosis in a dog with a successful outcome following the use of therapeutic\u00a0plasma exchange (TPE) and intralipid therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Summary<\/jats:title><jats:p>An 8\u2010month\u2010old female neutered poodle mix dog ingested an unknown amount of powered bifenthrin, which resulted in acutely altered mentation, cranial nerve deficits, and intractable tremors that persisted in severity despite aggressive medical management to include intravenous fluids, intravenous lipid emulsion, anticonvulsant medications, and methocarbamol. TPE was initiated after lack of significant clinical improvement 12\u00a0hours after initial presentation. The dog underwent cardiopulmonary arrest (CPA) following approximately 1 plasma volume equivalent exchange. The dog was successfully resuscitated and showed marked improvement 12\u00a0hours postarrest and post\u2010TPE treatment. Serum bifenthrin concentrations were analyzed prior to TPE (445.38\u00a0ng\/mL) and \u223c10\u00a0hours after TPE (51.18\u00a0ng\/mL), which resulted in an 89% reduction in serum bifenthrin concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>New Information<\/jats:title><jats:p>TPE may be a promising adjunctive therapeutic modality for bifenthrin toxicosis in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13377","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T12:34:03Z","timestamp":1714998843000},"page":"291-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of bifenthrin toxicosis using therapeutic plasma exchange"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2899-3564","authenticated-orcid":false,"given":"Alyson H.","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca K.","family":"Davies","sequence":"additional","affiliation":[{"name":"Massachusets Veterinary Referral Hospital  Woburn Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Lab, College of Veterinary Medicine Kansas State University Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Ensley","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Lab, College of Veterinary Medicine Kansas State University Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Fritz","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Lab, College of Veterinary Medicine Kansas State University Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bky046"},{"issue":"9","key":"e_1_2_9_3_1","first-page":"1","article-title":"Tremor\u2010salivation syndrome in canine following pyrethroid\/permethrin intoxication","volume":"5","author":"Klainbart S","year":"2014","journal-title":"Pharm Anal Acta"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2007.10.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.21.03.0152"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15528"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12729"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12608"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01030.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkw002"},{"key":"e_1_2_9_11_1","unstructured":"United States Food and Drug Administration.Bioanalytical method validation guidance for industry. 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