{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:40:31Z","timestamp":1767836431665,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical course and treatment of 3 dogs with peripheral vasopressor extravasation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Series Summary<\/jats:title><jats:p>Although vasopressor extravasation (VE) is a well\u2010documented complication in human medicine, literature describing VE and its management in veterinary patients is sparse. VE increases patient morbidity by causing local tissue injury and necrosis. The gold standard treatment for VE, phentolamine, has been periodically limited in supply in human medicine and is not consistently available for use in veterinary medicine. An alternative protocol proposed for use in people with VE combines topical nitroglycerin application with subcutaneous terbutaline infiltration. In this report, a treatment protocol utilizing these therapies was used to treat 3 dogs with VE and secondary tissue injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>This report describes 3 cases of VE\u2010induced tissue injury in dogs. In addition, this report describes the use of perivascular terbutaline infiltration and topical nitroglycerin application as therapeutic management for VE in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13393","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T05:29:21Z","timestamp":1718947761000},"page":"393-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The use of injectable subcutaneous terbutaline and topical nitroglycerin ointment in the treatment of peripheral vasopressor extravasation in 3 dogs"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-5153","authenticated-orcid":false,"given":"Chele N.","family":"Lathroum","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernan Lizardo","family":"Angulo Bracho","sequence":"additional","affiliation":[{"name":"Gulf Coast Veterinary Specialists  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla M.","family":"Alessandrino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-9047","authenticated-orcid":false,"given":"Julie M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a42c5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118997246.ch4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.90.6.806"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13394"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020903406"},{"issue":"9","key":"e_1_2_8_7_1","first-page":"581","article-title":"Alternative pharmacological management of vasopressor extravasation in the absence of phentolamine","volume":"42","author":"Plum M","year":"2017","journal-title":"P T"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195801000-00007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197905313002226"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"46","article-title":"Vascular effects of stereoisomers of dobutamine","volume":"224","author":"Ruffolo RR","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13406"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.01.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.01.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.04.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2017.09.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066616686035"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2394"},{"key":"e_1_2_8_18_1","unstructured":"Material and Safety Data Sheet: Terbutaline Sulfalte Injection USP.West Ward Pharmaceuticals;2019. Accessed November 15 2022.https:\/\/imgcdn.mckesson.com\/CumulusWeb\/Click_and_learn\/MSDS_9WEST_TERBUTALINE_SULF_SDV_1MG.pdf"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2019443"},{"key":"e_1_2_8_20_1","unstructured":"Norepinephrine. Lexi\u2010Drugs.Lexicomp;2022. Accessed November 24 2022.http:\/\/online.lexi.com\/"},{"key":"e_1_2_8_21_1","volume-title":"The Electronic Medicines Compendium (EMC)","year":"2020"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03016090"},{"issue":"2","key":"e_1_2_8_23_1","first-page":"113","article-title":"Stability of norepinephrine solutions in normal saline and 5% dextrose in water","volume":"63","author":"Walker SE","year":"2010","journal-title":"Can J Hosp Pharm"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02164.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15488"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:59:24Z","timestamp":1723136364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/vec.13393"],"URL":"https:\/\/doi.org\/10.1111\/vec.13393","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]},"assertion":[{"value":"2022-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}