{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:34:14Z","timestamp":1762432454729,"version":"3.40.5"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the short\u2010term response, early prognostic markers, and survival after treatment of canine immune\u2010mediated thrombocytopenia (ITP) with human intravenous immunoglobulin (hIVIG) and methylprednisolone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>Private referral veterinary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010seven client\u2010owned dogs with primary or secondary ITP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>All dogs received 2\u00a0mg\/kg IV methylprednisolone once daily and a single infusion of 5% hIVIG administered over 6\u201312\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>A substantial increase in platelet count within 60\u00a0\u00b1\u00a012\u00a0hours post\u2010hIVIG infusion (T<jats:sub>60<\/jats:sub>) was observed in 19 of the 27 (70%) dogs with ITP (responders). Thirty\u2010four variables, including serum immunoglobulin (Ig) G concentration 24\u00a0\u00b1\u00a012\u00a0hours post\u2010hIVIG infusion (T<jats:sub>24<\/jats:sub>IgG) and increase in serum IgG concentration 24\u00a0\u00b1\u00a012\u00a0hours post\u2010hIVIG infusion (T<jats:sub>24<\/jats:sub>\u0394<jats:sub>IgG<\/jats:sub>), were compared between responders and nonresponders at 5 different time points. Mortality rates of responders and nonresponders were evaluated 14\u00a0days post\u2010hIVIG infusion. Serum T<jats:sub>24<\/jats:sub>IgG and serum T<jats:sub>24<\/jats:sub>\u0394<jats:sub>IgG<\/jats:sub> were both significantly higher at T<jats:sub>60<\/jats:sub> in responders. All responders were alive 14\u00a0days post\u2010hIVIG infusion, and their mortality rate was significantly lower compared with nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Responder dogs had an excellent 14\u2010day survival rate. Serum T<jats:sub>24<\/jats:sub>IgG and serum T<jats:sub>24<\/jats:sub>\u0394<jats:sub>IgG<\/jats:sub> concentrations accurately predicted response status at 60\u00a0hours post\u2010hIVIG infusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13408","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:54:05Z","timestamp":1721652845000},"page":"465-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective evaluation of the short\u2010term response of human intravenous immunoglobulin therapy in the management of canine immune\u2010mediated thrombocytopenia (2010\u20132015): 27 cases"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-0360","authenticated-orcid":false,"given":"Andrea","family":"Zoia","sequence":"first","affiliation":[{"name":"Division of Internal Medicine San Marco Veterinary Clinic  Veggiano 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