{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:46:01Z","timestamp":1764002761049,"version":"3.30.2"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety of repeated administration of a lyophilized canine\u2010specific albumin (CSA) product and to quantify its effect on serum albumin concentrations and colloid osmotic pressure (COP) in healthy dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University research facility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six healthy, adult, purpose\u2010bred Beagles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Dogs received 1\u00a0g\/kg of 16% CSA intravenously on days 1, 2, and 14 and were observed, with serial measurement of vital parameters during and for 2\u00a0hours after each infusion, to monitor for adverse events or evidence of a hypersensitivity reaction. Serum albumin concentration and COP were measured at predetermined time points before and after each infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One dog experienced a single episode of vomiting approximately 1\u00a0hour after completion of the second infusion. No other adverse reactions were observed during the 28\u2010day study period. Serum albumin concentration was increased by a mean of 0.57\u00a0g\/dL (5.7\u00a0g\/L) (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003) when measured 2\u00a0hours after the first CSA infusion, and albumin concentration remained significantly higher than baseline at 24\u00a0hours after infusion, with a mean difference of 0.42\u00a0g\/dL (4.2\u00a0g\/dL) (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). The second and third CSA infusions similarly increased serum albumin concentration at 2\u00a0hours (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001 and <jats:italic>P\u00a0<\/jats:italic>=\u00a00.001, respectively) and 24\u00a0hours (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.012 and <jats:italic>P\u00a0<\/jats:italic>=\u00a00.007, respectively) after infusion. COP increased by a mean of 2.03\u00a0mm\u00a0Hg at 2\u00a0hours after the first infusion (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.013) and remained significantly higher than baseline at 24\u00a0hours after infusion, with a mean difference of 1.52\u00a0mm\u00a0Hg (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.002). The second CSA infusion similarly increased COP at 2\u00a0hours (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and 24\u00a0hours (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.017) after infusion. The third CSA infusion increased COP at 2\u00a0hours after infusion (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.004) but did not achieve statistical significance at 24\u00a0hours after infusion (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 1\u2010g\/kg dose of lyophilized CSA was effective at increasing serum albumin concentration and COP. Repeated infusions of CSA appear safe in healthy dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.13432","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T05:09:56Z","timestamp":1731992996000},"page":"524-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the safety and effect of lyophilized canine\u2010specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-6534","authenticated-orcid":false,"given":"Brittany D.","family":"Enders","sequence":"first","affiliation":[{"name":"Small Animal Emergency and Triage Services North Carolina State University Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-0601","authenticated-orcid":false,"given":"Sarah E.","family":"Musulin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-6970","authenticated-orcid":false,"given":"Marie K.","family":"Holowaychuk","sequence":"additional","affiliation":[{"name":"Reviving Veterinary Medicine Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne S.","family":"Hale","sequence":"additional","affiliation":[{"name":"Zia Pet Hospital Rio Rancho New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.09.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2020.07.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.802507"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12492"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118933053.ch4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.7.1004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.6.873"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2010.00526.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2005.00141.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.4.607"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcam.2022.100636"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12976"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13188"},{"key":"e_1_2_10_15_1","unstructured":"Canine albumin lyophilized 5gm. Package insert.Hemosolutions LLC;2018."},{"key":"e_1_2_10_16_1","unstructured":"Canine albumin lyophilized 5gm. Package insert. Animal Blood Resources International;2019."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13090"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"A1","article-title":"Evaluation of a novel canine albumin solution in normal beagles (IVECCS abstract)","volume":"19","author":"Smith CL","year":"2009","journal-title":"J Vet Emerg Crit Care"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00819.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13286"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13043"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.6.657"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1979.tb01527.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg233"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12925"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000169876.14858.91"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-3-4"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05341.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003800200038"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.13432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T12:43:10Z","timestamp":1734439390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.13432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/vec.13432"],"URL":"https:\/\/doi.org\/10.1111\/vec.13432","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"type":"print","value":"1479-3261"},{"type":"electronic","value":"1476-4431"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2023-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}