{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:22:39Z","timestamp":1759537359488,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To describe the clinical presentation of a dog with eunatremic, eukalemic hypoadrenocorticism (EEH) with multifocal, asymmetrical neurological signs.<\/jats:p><\/jats:sec>Case Summary<\/jats:title>A 7\u2010year\u2010old neutered male miniature Poodle presented for collapse, vomiting, and acute onset of neurological signs. The dog was obtunded and nonambulatory, with a right\u2010sided head tilt and turn with rotary nystagmus. No seizure activity was observed by the owner. The patient was in hypovolemic shock. Hypoglycemia, mild azotemia, and metabolic acidosis characterized by hyperlactatemia were identified. Magnetic resonance imaging of the brain and CSF analysis performed within 24\u00a0h of presentation were unremarkable. ACTH stimulation testing confirmed hypoadrenocorticism. Neurological signs failed to significantly improve despite systemic stabilization, glucose supplementation, and dexamethasone administration until approximately 48\u00a0h following admission. A mild proprioceptive ataxia was present at discharge approximately 84\u00a0h following admission and had resolved by the time of initial recheck 7\u00a0days following discharge.<\/jats:p><\/jats:sec>New Information Provided<\/jats:title>EEH can cause neurological signs with forebrain localization that are typically symmetrical due to the global nature of the injury. To the authors\u2019 knowledge, this is the first report of a dog with EEH presenting with severe, asymmetric, and multifocal neurological signs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.70019","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T15:37:43Z","timestamp":1756568263000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Multifocal Neurological Signs in a Dog With Eunatremic, Eukalemic Hypoadrenocorticism With Severe Hypoglycemia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-9066","authenticated-orcid":false,"given":"Cameron A. D.","family":"Morris","sequence":"first","affiliation":[{"name":"Critical Care Department Queensland Veterinary Specialists Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-2493","authenticated-orcid":false,"given":"Rebekah E.","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Critical Care Department Queensland Veterinary Specialists Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143458"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12243"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/VMRR.S125617"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.8.1190"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb02377.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1996.208.01.85"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3486"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-020-00111-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.848405"},{"key":"e_1_2_9_11_1","first-page":"474","volume-title":"Small Animal Critical Care Medicine","author":"Burkitt Creedon J.","year":"2022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15245"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.1999.0342"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0544-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L307"},{"volume-title":"StatPearls","year":"2022","author":"Mathew P.","key":"e_1_2_9_16_1"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T04:51:51Z","timestamp":1759467111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/vec.70019"],"URL":"https:\/\/doi.org\/10.1111\/vec.70019","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"type":"print","value":"1479-3261"},{"type":"electronic","value":"1476-4431"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2023-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}