{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:16:37Z","timestamp":1783653397349,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the cardiovascular and respiratory effects of bolus IV isotonic crystalloid fluid therapy before pericardiocentesis in dogs with pericardial effusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, randomized, nonblinded clinical trial (January 2021 to November 2022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty dogs diagnosed with pericardial effusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Dogs were randomized to receive a 10\u2010mL\/kg IV bolus of compound sodium lactate (IV fluid bolus [IVFB] group) or no fluid bolus (no\u2010IVFB group) over 10 min before pericardiocentesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Cardiovascular parameters, respiratory rate, peripheral blood lactate concentration, and point\u2010of\u2010care ultrasound (POCUS) findings were assessed. Shock index (SI) was calculated as heart rate divided by systolic blood pressure. Measurements were recorded at four time points (T): baseline (T0), 15 min later (T1, after fluid bolus for the IVFB group), immediately after pericardiocentesis (T2), and 4\u00a0h after pericardiocentesis (T3). Significant decreases in SI were observed in the no\u2010IVFB group between T1 and T2 and between T1 and T3, and in the IVFB group between T1 and T3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003, and\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027, respectively). No differences in SI were found between the groups when compared at the same time point. Administration of an IVFB did not result in adverse respiratory effects, as no dogs required supplemental oxygen by T3, and there were no differences in respiratory rate. The no\u2010IVFB group had a higher incidence of new B\u2010lines compared with the IVFB group (60% vs. 20%), but the median B\u2010line score was \u22641 at all POCUS sites at T0 and T3. Twenty\u2010four dogs survived to hospital discharge with no difference in survival between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Administering an IVFB of 10\u00a0mL\/kg isotonic crystalloid before pericardiocentesis in dogs with pericardial effusion did not alter SI. This dose appears to be safe, with no adverse respiratory effects seen. However, the current study was underpowered to detect a significant difference, and further studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70073","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:44:36Z","timestamp":1771505076000},"page":"298-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravenous Bolus Fluid Therapy Versus No Fluid Therapy Prior to Pericardiocentesis in Dogs: A Randomized Controlled Trial in 30 Dogs"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-6610","authenticated-orcid":false,"given":"Nadine","family":"Jones","sequence":"first","affiliation":[{"name":"Veterinary Clinical Science and Services The Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Humm","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Science and Services The Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica W.","family":"Tinson","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Science and Services The Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"37","volume-title":"Small Animal Critical Care Medicine","author":"Laforcade A.","year":"2022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.2.265"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80309-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.737841"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.05.001"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"49","article-title":"Effects of Volume Expansion and Vasodilators in Acute Pericardial Tamponade","volume":"240","author":"Gascho J. 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