{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:56:11Z","timestamp":1773014171871,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the concentration versus time course profiles of urinary tissue inhibitor of metalloproteinase\u20102 (TIMP\u20102), insulin\u2010like growth factor\u2013binding protein\u20107 (IGFBP\u20107), and kidney injury molecule\u20101 (KIM\u20101) during repeated administrations of meloxicam, and determine whether these profiles differ from saline\u2010treated cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Placebo\u2010controlled experimental design performed in 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve healthy, adult, purpose\u2010bred female cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>\n                      Cats were randomly allocated to control and treatment groups. Cats in the treatment group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) received meloxicam 0.3\u00a0mg\/kg subcutaneously every 24\u00a0h for 31\u00a0days. Cats in the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) received saline (0.1\u00a0mL\/kg subcutaneously).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Urinary TIMP\u20102, IGFBP\u20107, KIM\u20101, and creatinine were measured every 4\u20136\u00a0days for 31\u00a0days, along with serum creatinine. In the treatment group, cats were determined to have renal injury if at least one kidney had histopathological evidence of tubular damage, basement membrane damage, and\/or interstitial inflammation. The urinary biomarker concentrations between control and renal injury groups were compared by calculating the area under the curve (AUC) for each biomarker normalized for urine creatinine (UC) concentration versus time course profile and reported as mean\u00a0\u00b1\u00a0SE. The AUC values for the two groups were compared statistically using an unpaired, two\u2010tailed\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test. The AUC for urinary IGFBP\u20107\/UC was higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0152) in the treatment group (0.042\u00a0\u00b1\u00a00.0062) compared to the control group (0.02676\u00a0\u00b1\u00a00.0018). The AUC for urinary KIM\u20101\/UC was higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0083) in the treatment group (0.034\u00a0\u00b1\u00a00.0055) compared to the control group (0.019\u00a0\u00b1\u00a00.0022). An increase in urinary TIMP\u20102 was detected in only 50% of the treatment group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary IGFBP\u20107 and KIM\u20101 increase in cats that develop acute kidney injury after repeated meloxicam administration. Further studies are needed before the clinical utility of these molecules as biomarkers for early acute kidney injury detection in cats can be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70076","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:55:09Z","timestamp":1768805709000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Urinary Tissue Inhibitor of Metalloproteinase\u20102 (TIMP\u20102), Insulin\u2010Like Growth Factor\u2013Binding Protein\u20107 (IGFBP\u20107), and Kidney Injury Molecule\u20101 (KIM\u20101) as Biomarkers for the Detection of Meloxicam\u2010Induced Kidney Injury in Cats"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-826X","authenticated-orcid":false,"given":"Matthew K.","family":"Wun","sequence":"first","affiliation":[{"name":"Department of Veterinary 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