{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:56:19Z","timestamp":1773014179819,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study was to describe the use of and complications associated with the administration of lyophilized platelets (LPs) in dogs with thrombocytopenia\u2010associated hemorrhage and those with nonthrombocytopenia\u2010associated hemorrhage. Secondary objectives were to report pretransfusion and posttransfusion values, including PCV, total plasma protein concentration, platelet count, blood product administration, and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study between 2018 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Two university veterinary teaching hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty\u2010eight dogs that received LPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five dogs received LPs due to thrombocytopenia\u2010associated hemorrhage, and 33 dogs received LPs due to nonthrombocytopenia\u2010associated hemorrhage. The platelet count was lower in dogs with thrombocytopenia\u2010associated hemorrhage, both before (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and after LP administration (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), compared with dogs with nonthrombocytopenia\u2010associated hemorrhage. Dogs with thrombocytopenia\u2010associated hemorrhage had lower PCV values before LP administration (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007), but no difference was noted at 6\u201312 or 12\u201324\u00a0h after LP administration. There was no difference in the transfusion of other blood products (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.620) or in survival to discharge (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a01.000). Potential complications were noted in 6% of dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LP administration may be considered for a variety of conditions, including both thrombocytopenia\u2010associated hemorrhage and nonthrombocytopenia\u2010associated hemorrhage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70080","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:05:53Z","timestamp":1769425553000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter Retrospective Evaluation of the Use of Lyophilized Platelets in Dogs"],"prefix":"10.1111","volume":"36","author":[{"given":"Sarah","family":"Nugen","sequence":"first","affiliation":[{"name":"VCA West Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-3017","authenticated-orcid":false,"given":"Rebecca A. L.","family":"Walton","sequence":"additional","affiliation":[{"name":"VCA West Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5125-7314","authenticated-orcid":false,"given":"Ryan","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of\u00a0Veterinary Clinical Sciences Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazhang","family":"Cai","sequence":"additional","affiliation":[{"name":"University of Georgia College of Veterinary Medicine  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Mochel","sequence":"additional","affiliation":[{"name":"University of Georgia College of Veterinary Medicine  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin Long","family":"Mays","sequence":"additional","affiliation":[{"name":"Department of\u00a0Veterinary Sciences University of Illinois  Champaign Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2009.00389.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15167"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2009.00454.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32833723fe"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2022.08.147"},{"key":"e_1_2_8_7_1","volume-title":"StatPearls","author":"Agarwal 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