{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:56:00Z","timestamp":1773014160168,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To report the use of cryosupernatant (CS) transfusion for the treatment of suspected vitamin K antagonist rodenticide (VKAR)\u2010associated coagulopathy in dogs and its impact on coagulation times.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective case series (2000\u20132017).<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University teaching hospital.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Seven dogs with hemorrhage associated with suspected VKAR intoxication treated with CS transfusion.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n CS transfusion.<\/jats:p>\n <\/jats:sec>\n \n Measurements and Main Results<\/jats:title>\n \n The median age was 3.0\u00a0years, with a median weight of 17.7\u00a0kg. Initial coagulation testing revealed median one\u2010stage prothrombin time and activated partial thromboplastin time of 697% and 393%, respectively, above control\/average of the reference range (CARR). The median dose of CS was 11.0\u00a0mL\/kg. One\u2010stage prothrombin time decreased (\n p<\/jats:italic>\n \u00a0=\u00a00.043) after CS transfusion to a median of 98% of CARR. Activated partial thromboplastin time (\n n<\/jats:italic>\n \u00a0=\u00a03) decreased to 114% of CARR (sample size precluded statistical analysis) upon recheck. All dogs received vitamin K supplementation, with an initial median subcutaneous dose of 4.11\u00a0mg\/kg. Initial median PCV and total plasma protein concentration were 27.0% and 4.5\u00a0g\/dL (45\u00a0g\/L), respectively, with posttransfusion PCV and total plasma protein concentration of 22.0% and 4.9\u00a0g\/dL, respectively. Six dogs showed resolution of observed clinical hemorrhage and were discharged. One dog was euthanized due to multi\u2010organ dysfunction. No transfusion reactions were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dogs with suspected VKAR intoxication showed resolution of clinical hemorrhage after CS transfusion. Compared with fresh frozen plasma, CS is an option for treating VKAR\u2010associated coagulopathy, despite lower factor IX activity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vec.70095","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:05:36Z","timestamp":1769425536000},"page":"84-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective Evaluation of Treatment of Coagulopathy Secondary to Suspected Vitamin K Antagonist Rodenticide Intoxication With Cryosupernatant Transfusion in Seven Dogs (2000\u20132017)"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-3160","authenticated-orcid":false,"given":"Alyx L.","family":"Tracy","sequence":"first","affiliation":[{"name":"Charleston Veterinary Referral Center Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Culler","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Group White Plains New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-1181","authenticated-orcid":false,"given":"Edward","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-4387","authenticated-orcid":false,"given":"Julien","family":"Guillaumin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"496","article-title":"Anticoagulant Rodenticide Toxicity in Dogs: A Retrospective Study of 349 Confirmed Cases in Saskatchewan","volume":"65","author":"Paulin M. V.","year":"2024","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.06.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.879179"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1992.tb00981.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-1-38"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50012-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03622.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12671"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13049"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(90)50028-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.4.516"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12834"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-4-200208200-00009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-020-00517-5"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.70095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.70095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:42:40Z","timestamp":1773009760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vec.70095"],"URL":"https:\/\/doi.org\/10.1111\/vec.70095","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}