{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:46:08Z","timestamp":1792053968403,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if the administration of 20% intravenous lipid emulsion (ILE) to healthy dogs at the standard antidotal dose induces a hypocoagulable state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, nonblinded, crossover study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve adult, purpose\u2010bred Beagles with no history of recent illness or underlying endocrine disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Treated dogs received 20% ILE using a standard protocol for management of intoxications: 2\u00a0mL\/kg bolus over 2\u00a0min, followed by 0.25\u00a0mL\/kg\/min for 60\u00a0min. Control dogs received lactated Ringer's solution (LRS) using the same dosing scheme. Dogs were randomly assigned to receive ILE or LRS, then received the alternate treatment after a 1\u2010week washout period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Viscoelastic coagulation monitoring parameters using a benchtop viscoelastic coagulation monitor, prothrombin time (PT), activated partial thromboplastic time, and platelet count were measured 5\u00a0min before and 5\u00a0min after interventions. Compared with LRS administration, there was an increase in clot formation time after ILE administration and a decrease in the alpha angle, amplitude at 10\u00a0min, and amplitude at 20\u00a0min. There was an increase in PT after LRS infusion. Otherwise, no differences were noted in PT, activated partial thromboplastic time, platelet counts, or remaining viscoelastic coagulation monitoring parameters for either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Viscoelastic findings were suggestive of a relative hypocoagulability after ILE administration. Although statistically significant, most of these values were still within the provided reference intervals, so the magnitude of change may not be clinically important. The increase in PT after LRS solution, while statistically significant, was clinically irrelevant. ILE was well tolerated at the antidotal dose and did not have a clinically relevant effect on coagulation in otherwise healthy dogs in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70099","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:44:51Z","timestamp":1776267891000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Effects of Intravenous Lipid Emulsion Administration on Coagulation Parameters in Healthy Dogs"],"prefix":"10.1111","volume":"36","author":[{"given":"Sarah M.","family":"Hayes","sequence":"first","affiliation":[{"name":"Small Animal Clinical Sciences, Department of Emergency and Critical Care University of Tennessee College of Veterinary Medicine  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Marshall","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, Department of Emergency and Critical Care University of Tennessee College of Veterinary Medicine  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Bergee","sequence":"additional","affiliation":[{"name":"Research Computing Support, Office of Innovative Technologies University of Tennessee  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Schildt","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, Department of Emergency and Critical Care University of Tennessee College of Veterinary Medicine  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"More Than 400,000 Animals Assisted by ASPCA Animal Poison Control Center in 2023"},{"key":"e_1_2_12_3_1","volume-title":"Top 10 Pet Toxins of 2023"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2011.00686.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/jaaha\u2010ms\u20105761"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.07.006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2024.24510"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2016.1214275"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051396"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553\u20102712.2009.00499.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181\u2010010\u20100125\u20103"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1272705"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5326\/jaaha\u2010ms\u20106921"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.10.1328"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/vmrr.s129576"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.12.1455"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.241.8.1059"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12307"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12378"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.18849\/ve.v3i2.166"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2016.1151528"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"155","article-title":"Hypertriglyceridemia and Transient Corneal Lipidosis in a Cat Following Intravenous Lipid Therapy for Permethrin Toxicosis","volume":"59","author":"Yuh E. 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