{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:16:13Z","timestamp":1783653373754,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare serum syndecan\u20101 (SDC1) and hyaluronan (HA) concentrations in dogs receiving sevoflurane or isoflurane during general anesthesia and to assess factors associated with changes in these biomarkers during anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty\u2010eight client\u2010owned dogs scheduled for magnetic resonance imaging and potential surgery for intervertebral disc disease were enrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Dogs were randomly assigned to either the isoflurane or sevoflurane group, with 14 dogs in each group. Serum SDC1 and HA concentrations were measured before and after anesthesia using commercial ELISA kits validated for dogs. Primary outcomes were SDC1 and HA concentrations before and after anesthesia, as well as their changes during anesthesia, defined as postanesthetic minus preanesthetic biomarker concentration (\u0394SDC1 and \u0394HA). Secondary outcomes included duration of anesthesia, intraoperative medications, perioperative complications, and total intravenous crystalloid volume administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      No significant differences in postanesthetic SDC1 were observed between the sevoflurane (14.3\u00a0ng\/mL, 6.5\u201340.6) and isoflurane groups (20.0\u00a0ng\/mL, 13.6\u201324.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.129). Similarly, postanesthetic HA concentrations did not differ significantly between the sevoflurane (14.2\u00a0ng\/mL, 7.3\u201336.8) and isoflurane groups (14.2\u00a0ng\/mL, 0.32\u201344.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.560). However, HA levels significantly decreased after anesthesia in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No differences in endothelial glycocalyx effects were observed between groups that received sevoflurane or isoflurane anesthesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70115","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:11:13Z","timestamp":1778217073000},"page":"317-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Endothelial Glycocalyx Biomarkers in Dogs Anesthetized With Isoflurane or Sevoflurane: A Randomized, Prospective Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Wan\u2010Chu","family":"Hung","sequence":"first","affiliation":[{"name":"Auburn University  Auburn Alabama USA"},{"name":"University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Harris","sequence":"additional","affiliation":[{"name":"Auburn University  Auburn Alabama USA"},{"name":"Animal Medical &amp; Surgical Center  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart C.","family":"Clark\u2010Price","sequence":"additional","affiliation":[{"name":"Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"McMichael","sequence":"additional","affiliation":[{"name":"Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine K.","family":"Gerken","sequence":"additional","affiliation":[{"name":"Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendon W.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Yanke","sequence":"additional","affiliation":[{"name":"Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12925"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0212-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.82.7.566"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12418"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.875339"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2022.105845"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0719-81322020000300095"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000065917.53950.75"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182975b85"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318157e926"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.02.06.db05-1103"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680590894966"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318226113d"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.684852"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.02.014"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2011.10.001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.191585"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-016-2195-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182289988"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq019"},{"key":"e_1_2_11_22_1","first-page":"81","article-title":"Sevoflurane Mitigates Shedding of Hyaluronan From the Coronary Endothelium, Also During Ischemia\/Reperfusion: An Ex Vivo Animal Study","volume":"4","author":"Chen C.","year":"2016","journal-title":"Hypoxia"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.03.018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200310000-00023"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034265"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-014-1887-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-024-00602-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2020.105578"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17121"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200306000-00010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001195"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001403"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2015.02.010"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0797-4"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.11.016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.00170.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.4.941"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1984.tb00235.x"},{"issue":"2","key":"e_1_2_11_39_1","first-page":"532","article-title":"Removal Rate of [3H] Hyaluronan Injected Subcutaneously in Rabbits","volume":"259","author":"Reed R. 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