{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:17:07Z","timestamp":1783653427786,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To compare the performance of one point\u2010of\u2010care activated clotting time (ACT) machine (Vet\u2010Tube), one point\u2010of\u2010care activated partial thromboplastin time (aPTT) machine (Coagulation DX), and one bench\u2010top ACT machine (Medtronic ACT II plus) with previously published measurements from stationary devices in whole blood from healthy horses.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective, observational study<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University veterinary teaching hospital, from August 2023 to September 2023.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Thirty healthy university\u2010owned horses.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n ACT and aPTT were measured via point\u2010of\u2010care analyzers (ACT POC, aPTT POC) and by conventional stationary analyzers (ACT Stationary, aPTT Stationary) in non\u2010heparinized and heparinized blood collected from healthy horses. Samples were analyzed within 30\u00a0min of collection.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Moderate correlation (\n r<\/jats:italic>\n \u00a0=\u00a00.5), acceptable bias, and a low intraassay coefficient of variation (<5%) were seen for the ACT stationery device and ACT POC coagulation tubes. The ACT stationery and ACT POC showed no significant difference for both non\u2010heparinized (\n n<\/jats:italic>\n \u00a0=\u00a030,\n p<\/jats:italic>\n \u00a0=\u00a00.64) and heparinized samples (\n n<\/jats:italic>\n \u00a0=\u00a015,\n p<\/jats:italic>\n \u00a0=\u00a00.43). Strong correlation but high bias and a high intraassay coefficient of variation (>5%) were seen for the aPTT POC device, with the aPTT stationary device being within previously published ranges. The aPTT stationary chemistry analyzer and aPTT POC showed a significant difference for non\u2010heparinized samples (\n n<\/jats:italic>\n \u00a0=\u00a030,\n p<\/jats:italic>\n \u00a0=\u00a00.0002) but had no significant difference for heparinized samples (\n n<\/jats:italic>\n \u00a0=\u00a015,\n p<\/jats:italic>\n \u00a0=\u00a00.03).\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Relevance<\/jats:title>\n The results of this study provide proof of concept for the use of low\u2010cost POC monitoring of ACT in equine patients with coagulopathy or undergoing heparin therapy. Rigorous evaluation in patients with clinical disease is still necessary.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vec.70127","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:54:21Z","timestamp":1781013261000},"page":"330-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Point\u2010of\u2010Care Coagulation Measurement Systems for Activated Clotting Time and Partial Thromboplastin Time in Heparinized and Non\u2010Heparinized Equine Blood"],"prefix":"10.1111","volume":"36","author":[{"given":"Kallie J.","family":"Hobbs","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Texas A&M University College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethanie L.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Katie","family":"Sheats","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2009.04.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2008.05.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2014.04.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1414426"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17094"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051338"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12049"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870902100512"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1975.36.05.711"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1993.203.01.105"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17154"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/200840193"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659120948435"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16670"},{"key":"e_1_2_11_16_1","first-page":"69","article-title":"Statistics Corner: A Guide to Appropriate Use of Correlation Coefficient in Medical Research","volume":"24","author":"Mukaka M. 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